V
Virginia Goss Tusher
Researcher at Stanford University
Publications - 7
Citations - 14379
Virginia Goss Tusher is an academic researcher from Stanford University. The author has contributed to research in topics: Gene & Significance analysis of microarrays. The author has an hindex of 5, co-authored 7 publications receiving 13988 citations.
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Journal ArticleDOI
Significance analysis of microarrays applied to the ionizing radiation response
TL;DR: A method that assigns a score to each gene on the basis of change in gene expression relative to the standard deviation of repeated measurements is described, suggesting that this repair pathway for UV-damaged DNA might play a previously unrecognized role in repairing DNA damaged by ionizing radiation.
Journal ArticleDOI
Empirical Bayes analysis of a microarray experiment
TL;DR: A simple nonparametric empirical Bayes model is introduced, which is used to guide the efficient reduction of the data to a single summary statistic per gene, and also to make simultaneous inferences concerning which genes were affected by the radiation.
Patent
Significance analysis of microarrays
TL;DR: Significance analysis of microarrays (SAM) as mentioned in this paper assigns a score to each gene based on the change in gene expression relative to the standard deviation of repeated measurements, and uses permutations of the repeated measurements to estimate the percentage of such genes identified by chance, the false discovery rate.
Journal ArticleDOI
Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage
Kerri E. Rieger,Wan-Jen Hong,Virginia Goss Tusher,Jean Y. Tang,Robert Tibshirani,Gilbert Chu +5 more
TL;DR: Transcriptional responses in 24 genes predicted radiation toxicity in 9 of 14 patients with no false positives among 43 controls with significant heterogeneity, and may enable physicians to predict toxicity and tailor treatment for individual patients.
Journal ArticleDOI
Global analysis of ATM polymorphism reveals significant functional constraint
Yvonne R. Thorstenson,Peidong Shen,Virginia Goss Tusher,Tierney L. Wayne,Ronald W. Davis,Gilbert Chu,Peter J. Oefner +6 more
TL;DR: A comprehensive survey of sequence variation in ATM in diverse human populations revealed that this region of the human ATM gene was significantly constrained relative to that of the orangutan, the Old World monkey, and the mouse, but not relative to those of the chimpanzee or the gorilla.