Vito G. Sasseville

TL;DR: The results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.

TL;DR: It is demonstrated that the accessory gene product Nef induces the production of two CC-chemokines, macrophage inflammatory proteins 1α and 1β, by HIV-1-infected macrophages, indicating a role for Nef in lymphocyte recruitment and activation at sites of virus replication.

TL;DR: HIV entry into brain is a consequence of the ability of virus-infected and immune-activated monocytes to induce adhesion molecules on brain endothelium, and an association between macrophage infiltration and increased endothelial cell adhesion molecule was observed in encephalitic brains.

TL;DR: Rhesus monkeys naturally harbor a virus related to KSHV, which the authors have called RRV, for rhesus monkey rhadinovirus, which is a closer relatedness of the DNA polymerase and glycoprotein B reading frames to those of KSHv than to those in any other herpesvirus.

TL;DR: These findings identify an important determinant of the SIVpbj14 phenotype, and they provide evidence of a role for nef in signal transduction and cellular activation.