V
Vladimir Yu. Kiselev
Researcher at Wellcome Trust Sanger Institute
Publications - 29
Citations - 4257
Vladimir Yu. Kiselev is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cluster analysis & Consensus clustering. The author has an hindex of 16, co-authored 27 publications receiving 2528 citations. Previous affiliations of Vladimir Yu. Kiselev include Babraham Institute & University of Edinburgh.
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Journal ArticleDOI
SC3: consensus clustering of single-cell RNA-seq data
Vladimir Yu. Kiselev,Kristina Kirschner,Michael T. Schaub,Michael T. Schaub,Tallulah S. Andrews,Andrew Yiu,Tamir Chandra,Tamir Chandra,Kedar Nath Natarajan,Kedar Nath Natarajan,Wolf Reik,Wolf Reik,Wolf Reik,Mauricio Barahona,Anthony R. Green,Martin Hemberg +15 more
TL;DR: It is demonstrated that SC3 is capable of identifying subclones from the transcriptomes of neoplastic cells collected from patients and achieves high accuracy and robustness by combining multiple clustering solutions through a consensus approach.
Journal ArticleDOI
Challenges in unsupervised clustering of single-cell RNA-seq data.
TL;DR: This Review discusses the multiple algorithmic options for clustering scRNA-seq data, including various technical, biological and computational considerations.
Journal ArticleDOI
scmap: projection of single-cell RNA-seq data across data sets
TL;DR: Scmap is presented, a method for projecting cells from an scRNA-seq data set onto cell types or individual cells from other experiments, as well as a guide for comparing data across experiments.
Journal ArticleDOI
Predicting the mutations generated by repair of Cas9-induced double-strand breaks
Felicity Allen,Luca Crepaldi,Clara Alsinet,Alexander Strong,Vitalii Kleshchevnikov,Pietro De Angeli,Petra Páleníková,Anton Khodak,Vladimir Yu. Kiselev,Michael Kosicki,Andrew R. Bassett,Heather P. Harding,Yaron Galanty,Francisco Muñoz-Martínez,Emmanouil Metzakopian,Stephen P. Jackson,Leopold Parts,Leopold Parts +17 more
TL;DR: This work systematically study the influence of flanking DNA sequence on repair outcome by measuring the edits generated by >40,000 guide RNAs (gRNAs) in synthetic constructs and uncover sequence determinants of the mutations produced and use these to derive a predictor of Cas9 editing outcomes.
Journal ArticleDOI
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
Michael Snyder,Shin Lin,Amanda Posgai,Mark A. Atkinson,Aviv Regev,Jennifer Rood,Orit Rozenblatt-Rosen,Leslie Gaffney,Anna Hupalowska,Rahul Satija,Nils Gehlenborg,Jay Shendure,Julia Laskin,Pehr B. Harbury,Nicholas A. Nystrom,Jonathan C. Silverstein,Ziv Bar-Joseph,Kun Zhang,Katy Börner,Yiing Lin,Richard Conroy,Dena Procaccini,Ananda L. Roy,Ajay Pillai,Marishka Brown,Zorina S. Galis,Caltech-UW Tmc,Long Cai,Cole Trapnell,Dana Jackson,Stanford-WashU Tmc,Garry P. Nolan,William J. Greenleaf,Sylvia K. Plevritis,Sara Ahadi,Stephanie A. Nevins,Hayan Lee,Christian Martijn Schuerch,Sarah Black,Vishal G. Venkataraaman,Ed Esplin,Aaron M. Horning,Amir Bahmani,Ucsd Tmc,Xin bSun,Sanjay Jain,James S. Hagood,Gloria S. Pryhuber,Peter V. Kharchenko,Bernd bBodenmiller,Todd M. Brusko,Michael J. Clare-Salzler,Harry S. Nick,Kevin J. Otto,Clive hWasserfall,Marda Jorgensen,Maigan A. Brusko,Sergio Maffioletti,Richard M. Caprioli,Jeffrey M. Spraggins,Danielle cGutierrez,Nathan Heath Patterson,Elizabeth K. Neumann,Raymond C. Harris,Mark P. deCaestecker,Agnes B. Fogo,Raf Van de Plas,Ken S. Lau,Guo-Cheng Yuan,Qian Zhu,Ruben Dries,Harvard Ttd,Peng Yin,Sinem K. Saka,Jocelyn Y. Kishi,Yu Wang,Isabel Goldaracena,Purdue Ttd,DongHye Ye,Kristin E. Burnum-Johnson,Paul D. Piehowski,Charles Ansong,Ying Zhu,Stanford Ttd,Tushar bDesai,Jay Mulye,Peter Chou,Monica Nagendran,Visualization HuBMAP Integration,Sarah A. Teichmann,Benedict aten,Robert F. dMurphy,Jian Ma,Vladimir Yu. Kiselev,Carl Kingsford,Allyson Ricarte,Maria Keays,Sushma A. Akoju,Matthew Ruffalo,Margaret Vella,Chuck McCallum,Leonard E. Cross,Samuel H. Friedman,Randy Heiland,Bruce Herr,Paul Macklin,Ellen M. Quardokus,Lisel Record,James P. Sluka,Griffin M. Weber,Engagement Component,Philip D. Blood,Alexander J. Ropelewski,William E. Shirey,Robin M. Scibek,Paula M. Mabee,W. Christopher Lenhardt,Kimberly Robasky,Stavros Michailidis,John C. Marioni,Andrew Butler,Tim Stuart,Eyal Fisher,Shila Ghazanfar,Gökcen Eraslan,Tommaso Biancalani,Eeshit Dhaval Vaishnav,Ananda L. Roy,Zorina S. Galis,Pothur Srinivas,Aaron Pawlyk,Salvatore Sechi,Elizabeth L. Wilder,James E. Anderson +133 more
TL;DR: The NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping.