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Vladislav Nyrov

Bio: Vladislav Nyrov is an academic researcher from Saint Petersburg State Polytechnic University. The author has co-authored 1 publications.

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Book ChapterDOI
26 Oct 2021
TL;DR: In this article, a pilot experiment focused upon four candidate genes for inclusion into creativity studies, namely neurotrophic factor gene (BDNF), α-actinin-3 protein encoding gene (ACTN3), angiotensin-converting enzyme 1 (ACE1), and serotonin-2A receptor gene (5HTR2A), is presented.
Abstract: Present-day state of the theory of genetic foundations of creative performance, primarily at the level of the dopaminergic, serotoninergic, and noradrenergic systems, as well as neuregulin 1 gene, arginine vasopressin receptor, and angiotensinogene, is briefly reviewed. Basic results of a pilot experiment, focused upon four candidate genes for inclusion into creativity studies, namely neurotrophic factor gene (BDNF), α-actinin-3 protein encoding gene (ACTN3), angiotensin-converting enzyme 1 (ACE1), and serotonin-2A receptor gene (5HTR2A), are presented. Strong correlations between high level of creativity, both verbal and figural, and both Val/Val BDNF genotype, and RR ACTN3 genotype, are demonstrated, along with its somewhat weaker correlation with II ACE genotype. Taking into account levels of activation of basic psychological defense mechanisms and stress coping strategies, proper for 22 practically normal Arctic dwellers, who were examined in the framework of our experiment, allowed to link these correlations to optimal adaptation abilities, and to prolonged life expectancy. Basing upon this result, plausibility of discerning between two facets of creativity, one being adaptive, another being non-adaptive, is discussed, the former concerned with primarily coping with life stress, the latter providing self-actualization. Interrelation between the inherited abilities and the acquired ones, forming subject matter of correspondingly genetic and creativity studies, is regarded as a representation of basic dichotomy between nature and culture.

2 citations


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Journal ArticleDOI
TL;DR: In this article , the authors evaluated many human genes and their non-human orthologs established for their role in the regulation of lifespan and provided an updated account of genetic factors associated with the extended lifespan and their interactive contributory role with cellular pathways.
Abstract: Aging is a complex process indicated by low energy levels, declined physiological activity, stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent developments in medical sciences and an increased availability of nutritional requirements has significantly increased the average human lifespan worldwide. Several environmental and physiological factors contribute to the aging process. However, about 40% human life expectancy is inherited among generations, many lifespan associated genes, genetic mechanisms and pathways have been demonstrated during last decades. In the present review, we have evaluated many human genes and their non-human orthologs established for their role in the regulation of lifespan. The study has included more than fifty genes reported in the literature for their contributions to the longevity of life. Intact genomic DNA is essential for the life activities at the level of cell, tissue, and organ. Nucleic acids are vulnerable to oxidative stress, chemotherapies, and exposure to radiations. Efficient DNA repair mechanisms are essential for the maintenance of genomic integrity, damaged DNA is not replicated and transferred to next generations rather the presence of deleterious DNA initiates signaling cascades leading to the cell cycle arrest or apoptosis. DNA modifications, DNA methylation, histone methylation, histone acetylation and DNA damage can eventually lead towards apoptosis. The importance of calorie restriction therapy in the extension of lifespan has also been discussed. The role of pathways involved in the regulation of lifespan such as DAF-16/FOXO (forkhead box protein O1), TOR and JNK pathways has also been particularized. The study provides an updated account of genetic factors associated with the extended lifespan and their interactive contributory role with cellular pathways.

8 citations