V
Volker Lohmann
Researcher at Heidelberg University
Publications - 131
Citations - 18550
Volker Lohmann is an academic researcher from Heidelberg University. The author has contributed to research in topics: Viral replication & Hepatitis C virus. The author has an hindex of 63, co-authored 123 publications receiving 17750 citations. Previous affiliations of Volker Lohmann include University of Mainz.
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Journal ArticleDOI
Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line
TL;DR: This work defines the structure of HCV replicons functional in cell culture and provides the basis for a long-sought cellular system that should allow detailed molecular studies ofHCV and the development of antiviral drugs.
Journal ArticleDOI
Replication of the hepatitis C virus
TL;DR: This review summarizes the current knowledge about HCV replication and describes attempts pursued in the last few years to establish efficient and reliable cell culture systems.
Journal ArticleDOI
Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons
Rainer Gosert,Denise Egger,Volker Lohmann,Ralf Bartenschlager,Hubert E. Blum,Kurt Bienz,Darius Moradpour +6 more
TL;DR: Metabolic labeling with 5-bromouridine 5′-triphosphate in the presence of actinomycin D revealed that the membranous web is the site of viral RNA synthesis and therefore represents the replication complex of HCV.
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Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations.
TL;DR: Cell culture-adaptive mutations enhance HCV RNA replication and are corroborated with replicons in which the selectable marker gene was replaced by the gene encoding firefly luciferase.
Journal ArticleDOI
Replication of hepatitis C virus.
TL;DR: This review summarizes the current knowledge about HCV replication and describes attempts pursued in the last few years to establish efficient and reliable cell culture systems.