Author
W.J. le Noble
Bio: W.J. le Noble is an academic researcher from State University of New York System. The author has contributed to research in topics: Solvolysis & Butyl chloride. The author has an hindex of 6, co-authored 19 publications receiving 627 citations.
Topics: Solvolysis, Butyl chloride, Pairing, Ambient pressure, Bond length
Papers
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500 citations
58 citations
TL;DR: The E- and Z-5deuterioadamantan-2-ols have been synthesized by an unambiguous route as discussed by the authors, and the 13C NMR spectra show the familiar 1:1:1 splitting of one of the C-5 or C-7 signals, thus allowing a definite assignment of the δ-atoms.
Abstract: The E- and Z-5-deuterioadamantan-2-ols have been synthesized by an unambiguous route. The 13C NMR spectra show the familiar 1:1:1 splitting of one of the C-5 or C-7 signals, thus allowing a definite assignment of the δ-atoms to be made. This assignment is in accord with the conclusion of Duddeck and Islam. Revised assignments are offered for the reported configurations of the 5-bromo- and -chloro-adamantan-2-ols, and several unusual remote deuterium isotope shifts are reported.
25 citations
TL;DR: This paper showed that π-donor p -substituents in a phenyl ring located in the 5 position of adamantanone can moderate its ability to affect face selection, but cannot reverse it.
18 citations
01 Jan 1978
TL;DR: It is probably fair to say that the lectures given here to date have been concerned primarily with physics, and with the physical properties of compounds and sometimes mixtures; in contrast, my remarks and those of my colleagues to follow are almost exclusively directed at chemistry and chemical properties as discussed by the authors.
Abstract: It is probably fair to say that the lectures given here to date have been concerned primarily with physics, and with the physical properties of compounds and sometimes mixtures; in contrast, my remarks and those of my colleagues to follow are almost exclusively directed at chemistry and chemical properties. It goes without saying, however, that the chemist who uses high pressure methodology depends very much indeed on the knowledge that has been gathered by the physicists and physical chemists.
7 citations
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TL;DR: It has become increasingly apparent that the behavior of Lewis bases as agents for promoting chemical reactions is not merely as an electronic complement of the cognate Lewis acids: in fact Lewis bases are capable of enhancing both the electrophilic and nucleophilic character of molecules to which they are bound.
Abstract: The legacy of Gilbert Newton Lewis (1875-1946) pervades the lexicon of chemical bonding and reactivity. The power of his concept of donor-acceptor bonding is evident in the eponymous foundations of electron-pair acceptors (Lewis acids) and donors (Lewis bases). Lewis recognized that acids are not restricted to those substances that contain hydrogen (Bronsted acids), and helped overthrow the "modern cult of the proton". His discovery ushered in the use of Lewis acids as reagents and catalysts for organic reactions. However, in recent years, the recognition that Lewis bases can also serve in this capacity has grown enormously. Most importantly, it has become increasingly apparent that the behavior of Lewis bases as agents for promoting chemical reactions is not merely as an electronic complement of the cognate Lewis acids: in fact Lewis bases are capable of enhancing both the electrophilic and nucleophilic character of molecules to which they are bound. This diversity of behavior leads to a remarkable versatility for the catalysis of reactions by Lewis bases.
1,050 citations
TL;DR: Estimates of the speciation of major, minor, and trace elements in hydrothermal and metamorphic fluids throughout most of the crust of the Earth are facilitated by correlations among experimentally determined standard partial molal thermodynamic properties.
939 citations
TL;DR: In this paper, a line of distinction between the mechanistic alternatives for the Diels-Alder reaction was drawn, considering all experimental and theoretical criteria, for one-step and two-step reactions.
Abstract: The question of concerted or consecutive bond formation arises in all types of cycloaddition reactions. Stereochemical investigations and studies of regiospecificity as well as intensive kinetic investigations with regard to substituent and solvent effects, and the dependence of the reaction on temperature and pressure permit in many cases mechanistic conclusions concerning the Diels-Alder reaction. Efforts towards a theoretical interpretation, ab initio and semiempirical calculations, the application of frontier molecular orbital theory (FMO) as well as thermochemical measurements permit a description of the energy hypersurface of these [4+2]-cycloadditions. An attempt is made here to draw a line of distinction between the mechanistic alternatives—one-step reaction versus two-step reaction—considering all experimental and theoretical criteria.
827 citations
TL;DR: The goal of this overview is to show that pressure is a powerful tool for the study of proteins and modulation of enzymatic activity.
Abstract: Many biochemists would regard pressure as a physical parameter mainly of theoretical interest and of rather limited value in experimental biochemistry. The goal of this overview is to show that pressure is a powerful tool for the study of proteins and modulation of enzymatic activity.
701 citations
TL;DR: The Shilov-type Chemistry, “Catalytica” System for Catalytic Methane Functionalization, and Computational Studies of theShilov System are presented.
Abstract: 2.3. Hydrocarbon Coordination 2475 2.4. σ Complexes of Alkanes and Arenes 2475 2.5. Principle of Microscopic Reversibility 2476 2.6. Kinetic Isotope Effects 2477 3. Shilov-type Chemistry 2478 3.1. C−H Activation by Pt(II) 2479 3.2. Mechanism of Multiple H/D Exchange 2480 3.3. H/D Exchanges1,2 Shift in Ethane 2481 3.4. Computational Studies of the Shilov System 2481 3.5. C−H Activation by Pt(IV) 2482 4. “Catalytica” System for Catalytic Methane Functionalization 2482
689 citations