W
W. Matthijs Blankesteijn
Researcher at Maastricht University
Publications - 67
Citations - 4078
W. Matthijs Blankesteijn is an academic researcher from Maastricht University. The author has contributed to research in topics: Wnt signaling pathway & Frizzled. The author has an hindex of 30, co-authored 67 publications receiving 3556 citations. Previous affiliations of W. Matthijs Blankesteijn include University of California, Los Angeles.
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Journal ArticleDOI
Myocardial remodeling after infarction: the role of myofibroblasts
Susanne W.M. van den Borne,Javier Díez,W. Matthijs Blankesteijn,Johan W. Verjans,Leonard Hofstra,Jagat Narula +5 more
TL;DR: Defining molecular targets on myofibroblasts in conjunction with establishing the feasibility of molecular imaging of these cells might facilitate the early detection and treatment of patients who are at risk of developing heart failure after myocardial infarction.
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The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus.
Ewa Markiewicz,Katarzyna Tilgner,Nick Barker,Mark van de Wetering,Hans Clevers,Margareth Dorobek,Irena Hausmanowa-Petrusewicz,Frans C. S. Ramaekers,Jos L. V. Broers,W. Matthijs Blankesteijn,Georgia Salpingidou,Robert G. Wilson,Juliet A. Ellis,Christopher J. Hutchison +13 more
TL;DR: The results support recent findings that suggest that INM proteins can influence signalling pathways by restricting access of transcription coactivators to the nucleus by regulating the flux of β‐catenin into the nucleus.
Journal ArticleDOI
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone
B. Julie He,Mei Ling A. Joiner,Madhu V. Singh,Elizabeth D. Luczak,Paari Dominic Swaminathan,Olha M. Koval,William J. Kutschke,Chantal Allamargot,Jinying Yang,Xiaoqun Guan,Kathy Zimmerman,Isabella M. Grumbach,Robert M. Weiss,Douglas R. Spitz,Curt D. Sigmund,W. Matthijs Blankesteijn,Stephane Heymans,Stephane Heymans,Peter J. Mohler,Mark E. Anderson +19 more
TL;DR: It is shown that oxidized myocardial CaMKII mediates the cardiotoxic effects of aldosterone on the cardiac matrix and establish CaMK II as a nodal signal for the neurohumoral pathways associated with poor outcomes after myocardia infarction.
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WNT Signaling in Cardiac and Vascular Disease
Sébastien Foulquier,Evangelos P. Daskalopoulos,Gentian Lluri,Kevin C.M. Hermans,Arjun Deb,W. Matthijs Blankesteijn +5 more
TL;DR: A general picture is emerging that excessive stimulation of WNT signaling adversely affects cardiovascular pathology, and a rapidly increasing collection of drugs interfering at different levels of W NT signaling will allow the evaluation of therapeutic interventions in the pathway in relevant animal models of cardiovascular diseases and eventually in patients in the near future.
Journal ArticleDOI
A Role for the β-Catenin/T-Cell Factor Signaling Cascade in Vascular Remodeling
TL;DR: In conclusion, &bgr;-catenin and Tcf-4 play a dual role in vascular remodeling by inhibiting VSMC apoptosis and promoting proliferation.