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W. Tokarz

Bio: W. Tokarz is an academic researcher from AGH University of Science and Technology. The author has contributed to research in topics: Nanoparticle & Superconductivity. The author has an hindex of 7, co-authored 26 publications receiving 192 citations.

Papers
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Journal ArticleDOI
TL;DR: Very high value of the measured r2 relaxivity, 369 ± 3 mM−1 s−1, is conducive for the potential application of the obtained SPIONs as promising contrast agents in magnetic resonance imaging.
Abstract: This article presents the synthesis and characterization of biocompatible superparamagnetic iron oxide nanoparticles (SPIONs) coated with ultrathin layer of anionic derivative of chitosan. The water-based fabrication involved a two-step procedure. In the first step, the nanoparticles were obtained by co-precipitation of ferrous and ferric aqueous salt solutions with ammonia in the presence of cationic derivative of chitosan. In the second step, such prepared materials were subjected to adsorption of oppositely charged chitosan derivative which resulted in the preparation of negatively charged SPIONs. They were found to develop highly stable dispersion in water. The core size of the nanocoated SPIONs, determined using transmission electron microscopy, was measured to be slightly above 10 nm. The coated nanoparticles form aggregates with majority of them having hydrodynamic diameter below 100 nm, as measured by dynamic light scattering. Their composition and properties were studied using FTIR and thermogravimetric analyses. They exhibit magnetic properties typical for superparamagnetic material with a high saturation magnetization value of 123 ± 12 emu g−1 Fe. Very high value of the measured r2 relaxivity, 369 ± 3 mM−1 s−1, is conducive for the potential application of the obtained SPIONs as promising contrast agents in magnetic resonance imaging. Electronic supplementary material The online version of this article (doi:10.1007/s11051-012-1372-9) contains supplementary material, which is available to authorized users.

60 citations

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TL;DR: In this article, a layered double hydroxide (LDH) with Mg:Al molar ratio of 2:1 synthesized using co-precipitation method was impregnated with iron oxide particles (10 and 25% loading).

35 citations

Journal ArticleDOI
TL;DR: In this article, a method for synthesis of superparamagnetic iron oxide nanoparticles (SPION) modified with a cationic chitosan (CCh) and coated with a silica shell, SPION-CCh-SiO2 was developed.

31 citations

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TL;DR: In this paper, the results revealed the formation of inner-sphere complexes between As and composites surface as well as As(V) reduction coupled with Fe(II) oxidation as the main removal mechanisms.

25 citations

Journal ArticleDOI
TL;DR: In vitro tests indicate that both components of the hybrid nanoparticles may have a positive impact on the behavior of SAOS-2 cells cultivated on the PCL composite scaffolds.

25 citations


Cited by
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01 Jan 1912

1,225 citations

01 Apr 2010
TL;DR: Polycaprolactone (PCL) was used in the biomaterials field and a number of drug-delivery devices for up to 3-4 years as discussed by the authors.
Abstract: During the resorbable-polymer-boom of the 1970s and 1980s, polycaprolactone (PCL) was used in the biomaterials field and a number of drug-delivery devices. Its popularity was soon superseded by faster resorbable polymers which had fewer perceived disadvantages associated with long term degradation (up to 3-4 years) and intracellular resorption pathways; consequently, PCL was almost forgotten for most of two decades. Recently, a resurgence of interest has propelled PCL back into the biomaterials-arena. The superior rheological and viscoelastic properties over many of its aliphatic polyester counterparts renders PCL easy to manufacture and manipulate into a large range of implants and devices. Coupled with relatively inexpensive production routes and FDA approval, this provides a promising platform for the production of longer-term degradable implants which may be manipulated physically, chemically and biologically to possess tailorable degradation kinetics to suit a specific anatomical site. This review will discuss the application of PCL as a biomaterial over the last two decades focusing on the advantages which have propagated its return into the spotlight with a particular focus on medical devices, drug delivery and tissue engineering.

480 citations

Journal ArticleDOI
TL;DR: This review mainly focuses on the influence of spin canting effects, introduced by the variations in size, shape, and organic/inorganic surface coatings, on the magnetic properties of SPIONs.

301 citations

Journal ArticleDOI
TL;DR: Light scattering based techniques, namely dynamic light scattering and zeta-potential, used for the physicochemical characterization of nanoparticles are reviewed, focusing on nanoparticle characterization and application in infection, cancer and cardiovascular diseases.
Abstract: Copyright © 2018 Carvalho, Felicio, Santos, Goncalves and Domingues. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

186 citations

Journal ArticleDOI
TL;DR: In this article, the magnetic properties of superparamagnetic iNANOvative™|silica nanoparticle clusters were studied, with a special focus on the influence of the magnetic interactions between the nanoparticles in the core.

145 citations