Wade D. Van Horn

TL;DR: NMR titration of C99 reveals a binding site for cholesterol, providing mechanistic insight into how cholesterol promotes amyloidogenesis and may aid in the design of Alzheimer’s therapeutics.

TL;DR: The three-dimensional structure of the DAGK homotrimer is determined with the use of solution nuclear magnetic resonance, providing insight into the determinants of lipid substrate specificity and phosphotransferase activity.

TL;DR: Recent progress in the application of solution NMR of IMPs is highlighted to outline sample preparative and spectroscopic advances that have led to this breakthrough and there is reason to believe that this recent progress reflects only the beginning of a phase of exponential growth in the use of solutions NMR methods to solve important problems in membrane protein structural biology.

TL;DR: This review provides a structural perspective on known antiparallel duplex structures in which at least one strand of the Watson–Crick duplex is composed entirely of XNA.

TL;DR: The data presented here provide an important bridge between commonly employed dilute in vitro studies and studies of the effects of a crowded environment, as found in vivo, and reconcile alternative interpretations of protein cold denaturation within reverse micelles.