W
Walter Wahli
Researcher at Nanyang Technological University
Publications - 377
Citations - 52605
Walter Wahli is an academic researcher from Nanyang Technological University. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Nuclear receptor. The author has an hindex of 105, co-authored 365 publications receiving 49372 citations. Previous affiliations of Walter Wahli include University of Lausanne & French Institute of Health and Medical Research.
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Journal ArticleDOI
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
Béatrice Desvergne,Walter Wahli +1 more
TL;DR: This work has shown that direct expression of PPAR mRNAs in the absence of a specific carrier gene results in down-regulation in the activity of other PPARs, and these properties are consistent with those of a “spatially aggregating substance”.
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Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
TL;DR: This work presents the expression patterns of the PPAR subtypes in the adult rat, determined by in situ hybridization using specific probes for PPAR-alpha, -beta and -gamma, and by immunohistochemistry using a polyclonal antibody that recognizes the three rat PPar subtypes.
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Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Steven A. Kliewer,Scott S. Sundseth,Stacey A. Jones,Peter Brown,G. Bruce Wisely,Cecilia S. Koble,Pallavi R. Devchand,Walter Wahli,Timothy M. Willson,James M. Lenhard,Jürgen M. Lehmann +10 more
TL;DR: Evidence that PPARs serve as physiological sensors of lipid levels is provided and a molecular mechanism whereby dietary fatty acids can modulate lipid homeostasis is suggested.
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Roles of PPARs in health and disease.
TL;DR: The latest developments in the PPAR field are presented, with particular emphasis on the physiological function ofPPARs during various nutritional states, and the possible role of PPARs in several chronic diseases.
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Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Sander Kersten,Josiane Seydoux,Jeffrey M. Peters,Frank J. Gonzalez,Béatrice Desvergne,Walter Wahli +5 more
TL;DR: It is shown that to accommodate the increased requirement for hepatic fatty acid oxidation, PPAR α mRNA is induced during fasting in wildtype mice, indicating that PPARα plays a pivotal role in the management of energy stores during fasting.