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Waradon Sungnak
Researcher at Wellcome Trust Sanger Institute
Publications - 8
Citations - 3983
Waradon Sungnak is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 5, co-authored 6 publications receiving 2846 citations.
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Journal ArticleDOI
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
Waradon Sungnak,Ni Huang,Christophe Bécavin,Marijn Berg,Rachel Queen,Monika Litvinukova,Monika Litvinukova,Carlos Talavera-López,Henrike Maatz,Daniel Reichart,Fotios Sampaziotis,Kaylee B Worlock,Masahiro Yoshida,Josephine Barnes +13 more
TL;DR: In this paper, the expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors was investigated, and co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission.
Journal ArticleDOI
SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways
TL;DR: Analysis of the compendium of data points to a particularly relevant role for nasal goblet and ciliated cells as early viral targets and potential reservoirs of SARS-CoV-2 infection and underscores the importance of the availability of the Human Cell Atlas as a reference dataset.
Journal ArticleDOI
Single-cell multi-omics analysis of the immune response in COVID-19.
Emily Stephenson,Gary Reynolds,Rachel A. Botting,Fernando J Calero-Nieto,Michael D Morgan,Michael D Morgan,Zewen K. Tuong,Zewen K. Tuong,Karsten Bach,Karsten Bach,Waradon Sungnak,Kaylee B Worlock,Masahiro Yoshida,Natsuhiko Kumasaka,Katarzyna D. Kania,Justin Engelbert,Bayanne Olabi,Jarmila Stremenova Spegarova,Nicola K. Wilson,Nicole Mende,Laura Jardine,Louis C.S. Gardner,Issac Goh,Dave Horsfall,Jim McGrath,Simone Webb,Michael W. Mather,Rik G.H. Lindeboom,Emma Dann,Ni Huang,Krzysztof Polanski,Elena Prigmore,Florian Gothe,Florian Gothe,Jonathan M. Scott,Rebecca Payne,Kenneth F Baker,Kenneth F Baker,Aidan T Hanrath,Aidan T Hanrath,Ina Schim van der Loeff,Andrew Barr,Amada Sanchez-Gonzalez,Laura Bergamaschi,Federica Mescia,Josephine Barnes,Eliz Kilich,Angus de Wilton,A Saigal,Aarash Saleh,Sam M. Janes,Sam M. Janes,Claire Smith,Nusayhah Gopee,Caroline Wilson,Caroline Wilson,Paul Coupland,Jonathan Coxhead +57 more
TL;DR: In this article, the authors performed single-cell transcriptome, surface proteome and T and B lymphocyte antigen receptor analyses of over 780,000 peripheral blood mononuclear cells from a cross-sectional cohort of 130 patients with varying severities of COVID-19.
Posted ContentDOI
The cellular immune response to COVID-19 deciphered by single cell multi-omics across three UK centres
Emily Stephenson,Gary Reynolds,Rachel A. Botting,Fernando J Calero-Nieto,Michael D Morgan,Michael D Morgan,Zewen K. Tuong,Zewen K. Tuong,Karsten Bach,Karsten Bach,Waradon Sungnak,Kaylee B Worlock,Masahiro Yoshida,Natsuhiko Kumasaka,Katarzyna D. Kania,Justin Engelbert,Bayanne Olabi,Jarmila Stremenova Spegarova,Nicola K. Wilson,Nicole Mende,Laura Jardine,Louis C.S. Gardner,Issac Goh,Dave Horsfall,Jim McGrath,Simone Webb,Michael W. Mather,Rik G.H. Lindeboom,Emma Dann,Ni Huang,Krzysztof Polanski,Elena Prigmore,Florian Gothe,Jonathan M. Scott,Rebecca Payne,Kenneth F Baker,Aidan T Hanrath,Aidan T Hanrath,Ina Schim van der Loeff,Andrew Barr,Amada Sanchez-Gonzalez,Laura Bergamaschi,Federica Mescia,Josephine Barnes,Eliz Kilich,Angus de Wilton,A Saigal,Aarash Saleh,Sam M. Janes,Sam M. Janes,Claire Smith,Nusayhah Gopee,Caroline Wilson,Caroline Wilson,Paul Coupland,Jonathan Coxhead,Vladimir Yu. Kiselev,Stijn van Dongen,Jaume Bacardit,Hamish W King,Hamish W King,Anthony J. Rostron,A. John Simpson,Sophie Hambleton,Elisa Laurenti,Paul A Lyons,Kerstin B Meyer,Kerstin B Meyer,Marko Z Nikolic,Marko Z Nikolic,Chris Duncan,Kenneth G. C. Smith,Kenneth G. C. Smith,Sarah A. Teichmann,Menna R. Clatworthy,Menna R. Clatworthy,Menna R. Clatworthy,John C. Marioni,Berthold Göttgens,Muzlifah Haniffa +79 more
TL;DR: In this article, the authors performed single-cell RNA-sequencing coupled with analysis of cell surface proteins, providing molecular profiling of over 800,000 peripheral blood mononuclear cells from a cohort of 130 patients with COVID-19.
Posted ContentDOI
The local and systemic response to SARS-CoV-2 infection in children and adults
Masahiro Yoshida,Masahiro Yoshida,Kaylee B Worlock,Ni Huang,Rik G.H. Lindeboom,Colin R. Butler,Natsuhiko Kumasaka,Cecilia Domínguez Conde,Lira Mamanova,Liam Bolt,Laura Richardson,Krzysztof Polanski,Elo Madissoon,Elo Madissoon,Josephine Barnes,Jessica Allen-Hyttinen,Eliz Kilich,Brendan C Jones,Angus de Wilton,Anna Wilbrey-Clark,Waradon Sungnak,Jan Patrick Prett,Elena Prigmore,Henry Yung,Henry Yung,Puja Mehta,Puja Mehta,Aarash Saleh,A Saigal,Vivian Chu,Jonathan M. Cohen,Clare Cane,Aikaterini Iordanidou,Soichi Shibuya,Ann-Kathrin Reuschl,A. Christine Argento,Richard G. Wunderink,Sean B. Smith,Taylor A. Poor,Catherine A Gao,Jane Dematte,NU Script Study Investigators,Gary Reynolds,Muzlifah Haniffa,Georgina Bowyer,Matthew L Coates,Matthew L Coates,Menna R. Clatworthy,Fernando J Calero-Nieto,Berthold Göttgens,Neil J. Sebire,Clare Jolly,Paolo De Coppi,Claire Smith,Alexander V. Misharin,Sam M. Janes,Sam M. Janes,Sarah A. Teichmann,Sarah A. Teichmann,Marko Nikolic,Marko Nikolic,Kerstin B. Meyer +61 more
TL;DR: In this paper, a healthy reference multi-omics single cell data set from children (n=30) was generated and compared with equivalent data from severe paediatric and adult COVID-19 patients (total n=27), from the same three types of samples: upper and lower airways and blood.