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Warren J. Strittmatter
Researcher at Duke University
Publications - 162
Citations - 33565
Warren J. Strittmatter is an academic researcher from Duke University. The author has contributed to research in topics: Apolipoprotein E & Alzheimer's disease. The author has an hindex of 60, co-authored 160 publications receiving 32220 citations. Previous affiliations of Warren J. Strittmatter include University of California & Harvard University.
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Journal ArticleDOI
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
Elizabeth H. Corder,Ann M. Saunders,Warren J. Strittmatter,Donald E. Schmechel,P. C. Gaskell,Gary W. Small,A. D. Roses,Jonathan L. Haines,Margaret A. Pericak-Vance +8 more
TL;DR: The APOE-epsilon 4 allele is associated with the common late onset familial and sporadic forms of Alzheimer9s disease (AD) in 42 families with late onset AD.
Journal ArticleDOI
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.
Warren J. Strittmatter,Ann M. Saunders,Donald E. Schmechel,Margaret A. Pericak-Vance,Jan J. Enghild,Guy S. Salvesen,Allen D. Roses +6 more
TL;DR: It is demonstrated that there was a highly significant association of apolipoprotein E type 4 allele (APOE-epsilon 4) and late-onset familial Alzheimer disease.
Journal ArticleDOI
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.
Ann M. Saunders,Warren J. Strittmatter,Donald E. Schmechel,P. St. George-Hyslop,Margaret A. Pericak-Vance,S. H. Joo,B.L. Rosi,James F. Gusella,D. R. Crapper-MacLachlan,Mark J. Alberts,Christine M. Hulette,Barbara J. Crain,Dmitry Goldgaber,A. D. Roses +13 more
TL;DR: Data support the involvement of ApoE ϵ4 in the pathogenesis of late-onset familial and sporadic AD and suggest it may operate as a susceptibility gene (risk factor) for the clinical expression of AD.
Journal ArticleDOI
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease.
Elizabeth H. Corder,Ann M. Saunders,Neil Risch,Warren J. Strittmatter,Donald E. Schmechel,P. C. Gaskell,J. B. Rimmler,P. A. Locke,Conneally Pm,Kenneth E. Schmader +9 more
TL;DR: A protective effect of the ε2 allele, in addition to the dose effect ofThe ε4 allele in sporadic AD, is demonstrated, which further support the direct involvement of APOE in the pathogenesis of AD.
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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease
Donald E. Schmechel,Ann M. Saunders,Warren J. Strittmatter,Barbara J. Crain,Christine M. Hulette,S. H. Joo,Margaret A. Pericak-Vance,Dmitry Goldgaber,A. D. Roses +8 more
TL;DR: In an autopsy series of brains of late-onset AD patients, a strong association of APOE4 allele with increased vascular and plaque A beta deposits is found.