Wataru Ebina

TL;DR: It is shown that this approach can reprogram multiple human cell types to pluripotency with efficiencies that greatly surpass established protocols and represents a safe, efficient strategy for somatic cell reprogramming and directing cell fate that has broad applicability for basic research, disease modeling, and regenerative medicine.

TL;DR: It is shown that intramyocardial injection of synthetic modified RNA (modRNA) encoding human vascular endothelial growth factor-A (VEGF-A) results in the expansion and directed differentiation of endogenous heart progenitors in a mouse myocardial infarction model.

TL;DR: It is demonstrated that expression of a set of defined factors is sufficient to activate the gene networks governing HSC functional identity in committed blood cells, raising the prospect that blood cell reprogramming may be a strategy for derivation of transplantable stem cells for clinical application.

TL;DR: Fdg5 identifies bone marrow cells with potent hematopoietic stem cell activity that are compatible with bone marrow transplantation and promotes wound healing.

TL;DR: It is shown that transient ectopic co-expression of RAD52 and a dominant-negative form of tumour protein p53-binding protein 1 (dn53BP1) synergize to enable efficient HDR using a single-stranded oligonucleotide DNA donor template at multiple loci in human cells, including patient-derived induced pluripotent stem cells.