W
Wei Cui
Researcher at Imperial College London
Publications - 70
Citations - 4995
Wei Cui is an academic researcher from Imperial College London. The author has contributed to research in topics: Embryonic stem cell & Stem cell. The author has an hindex of 31, co-authored 66 publications receiving 4210 citations. Previous affiliations of Wei Cui include Geron Corporation & University of Minnesota.
Papers
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Journal ArticleDOI
Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination.
Jason S. L. Yu,Wei Cui +1 more
TL;DR: The recent in vitro and in vivo evidence for the role PI3K/AKT/mTOR signalling plays in the control of pluripotency and differentiation in stem cells is reviewed, with a particular focus on the molecular mechanisms underlying these functions.
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Efficient Differentiation of Hepatocytes from Human Embryonic Stem Cells Exhibiting Markers Recapitulating Liver Development In Vivo
David C. Hay,Debiao Zhao,Judy Fletcher,Zoe Hewitt,Doris McLean,Alai Urruticoechea-Uriguen,James R. Black,Cliff Elcombe,James A. Ross,Roland Wolf,Wei Cui,Wei Cui +11 more
TL;DR: Evidence is provided that hESCs can be differentiated efficiently in vitro to functional hepatocytes, which may be useful as an in vitro system for toxicity screening in drug discovery and evidence that the hESC‐derived hepatocytes are able to carry out a range of hepatocyte functions.
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Differentiation of Human Embryonic Stem Cells to Neural Lineages in Adherent Culture by Blocking Bone Morphogenetic Protein Signaling
TL;DR: It is shown that inhibition of bone morphogenetic protein signaling by its antagonist noggin is sufficient to block extraembryonic cell fate, transiently sustain Oct4 gene expression, and result in robust production of neural progenitors.
Journal ArticleDOI
Sox2, a key factor in the regulation of pluripotency and neural differentiation
Shuchen Zhang,Wei Cui +1 more
TL;DR: Recent findings concerning the involvement of Sox2 in pluripotency, somatic cell reprogramming and neural differentiation as well as the molecular mechanisms underlying these roles are reviewed.
Journal ArticleDOI
High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity.
Elisa Närvä,Reija Autio,Reija Autio,Nelly Rahkonen,Lingjia Kong,Neil J. Harrison,Danny Kitsberg,Lodovica Borghese,Joseph Itskovitz-Eldor,Omid Rasool,Petr Dvorak,Outi Hovatta,Timo Otonkoski,Timo Tuuri,Wei Cui,Oliver Brüstle,Duncan Baker,Edna Maltby,Harry Moore,Nissim Benvenisty,Peter W. Andrews,Olli Yli-Harja,Olli Yli-Harja,Riitta Lahesmaa +23 more
TL;DR: The highest-resolution study of hESCs to date using an Affymetrix SNP 6.0 array containing 906,600 probes for single nucleotide polymorphisms (SNPs) and 946,000 probes for copy number variations (CNVs) is reported, finding 843 CNVs of 50 kb–3 Mb in size.