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Wei Guo
Researcher at University of Texas MD Anderson Cancer Center
Publications - 57
Citations - 3575
Wei Guo is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Apoptosis & Cancer cell. The author has an hindex of 29, co-authored 55 publications receiving 3309 citations. Previous affiliations of Wei Guo include Zhejiang University & University of California, Los Angeles.
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Journal ArticleDOI
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
Ömer H. Yilmaz,Riccardo Valdez,Brian K. Theisen,Wei Guo,David O. Ferguson,Hong Wu,Sean J. Morrison +6 more
TL;DR: Mechanistic differences between normal stem cells and cancer stem cells can thus be targeted to depletecancer stem cells without damaging normalstem cells.
Journal ArticleDOI
Multi-genetic events collaboratively contribute to Pten -null leukaemia stem-cell formation
Wei Guo,Joseph L. Lasky,Chun Ju Chang,Sherly Mosessian,Xiaoman Lewis,Yun Xiao,Jennifer E. Yeh,James Y. Chen,M. Luisa Iruela-Arispe,Marileila Varella-Garcia,Hong Wu +10 more
TL;DR: It is shown that Pten deletion in mouse haematopoietic stem cells leads to a myeloproliferative disorder, followed by acute T-lymphoblastic leukaemia (T-ALL) and multiple genetic or molecular alterations contribute cooperatively to LSC transformation.
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Selective Deletion of Pten in Pancreatic β Cells Leads to Increased Islet Mass and Resistance to STZ-Induced Diabetes
Bangyan L. Stiles,Christine Kuralwalla-Martinez,Wei Guo,Caroline Gregorian,Ying Wang,Jide Tian,Mark A. Magnuson,Hong Wu +7 more
TL;DR: The data demonstrate that PTEN loss in β cells is not tumorigenic but beneficial, and suggests that modulating the PTEN-controlled signaling pathway is a potential approach for β-cell protection and regeneration therapies.
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Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors
Hongbo Zhu,Lidong Zhang,Fengqin Dong,Wei Guo,Shuhong Wu,Fuminori Teraishi,John J. Davis,John J. Davis,Paul J. Chiao,Bingliang Fang +9 more
TL;DR: Results suggested that Bik/NBK is one of the mediators of proteasome inhibitor-induced apoptosis, and was associated with bortezomib cytotoxicity and apoptosis induction.
Journal ArticleDOI
Cytoplasmic p27 promotes epithelial–mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation
Dekuang Zhao,Alexandra H. Besser,Seth A. Wander,Jun Sun,Wen Zhou,Bin Wang,Tan A. Ince,Michael A. Durante,Wei Guo,Gordon B. Mills,Dan Theodorescu,Joyce M. Slingerland +11 more
TL;DR: An oncogenic feedforward loop in which p27pT157pT198 binds Janus kinase 2 (JAK2) promoting STAT3 (signal transducer and activator of transcription 3) recruitment and activation is described.