Wei-Min Chen

TL;DR: This review critically describes the recent research on isolation, synthesis, and derivatization of BA and its natural analogs betulin and 23‐hydroxybetulinic acid and focuses on the current knowledge of antitumor properties, combination treatments, and pharmacological mechanisms of these compounds.

TL;DR: B5G1, a new derivative of BA, induces cell death in multidrug resistant cancer cells HepG2/ADM and MCF-7/ADR through mitochondrial-apoptosis pathway and provides the first demonstration that B5G 1, as a novel mitophagy inducer, has the potential to be developed into a drug candidate for treating multidrog resistant cancer.

TL;DR: It was discovered that activation of the ClC-3 Cl(-) channel, which subsequently induced inhibition of the PI3K/Akt/mTOR signaling pathway, was involved in the antitumor activities of bufadienolides.

TL;DR: The mechanism studies demonstrated that the anti-inflammatory activity of CSA and its derivative is associated with the inhibition of NF-κB and MAPK pathways, relying partly on resisting the LPS-induced decrease of PPARγ through improving its expression.

TL;DR: BBA can reverseABCB1-mediated MDR by inhibiting its efflux function of ABCB1, which supports the development of BBA as a novel potential MDR reversal agent used in the clinic.