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Wei Wang

Bio: Wei Wang is a academic researcher at Chinese Academy of Sciences who has co-authored 3544 publication(s) receiving 59660 citation(s). The author has an hindex of 95. Previous affiliations of Wei Wang include Cleveland Clinic Lerner Research Institute & South China Agricultural University. The author has done significant research in the topic(s): Population & Laser.

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Topics: Population, Laser, Cancer ... show more

3,544 results found

Open accessJournal ArticleDOI: 10.1038/SREP21230
23 Feb 2016-Scientific Reports
Abstract: Scientific Reports 5: Article number: 10942; published online: 01 June 2015; updated: 23 February 2016 This Article contains typographical errors in Table 2 where ‘Week 2 (N = 32)’ was incorrectly given as ‘Week (N = 2)’.

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Topics: Typographical error (50%)

2,328 Citations

Open accessJournal ArticleDOI: 10.1038/NATURE06250
Pardis C. Sabeti1, Pardis C. Sabeti2, Patrick Varilly1, Patrick Varilly2  +255 moreInstitutions (50)
18 Oct 2007-Nature
Abstract: With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms from the International HapMap Project Phase 2 (HapMap2). We used 'long-range haplotype' methods, which were developed to identify alleles segregating in a population that have undergone recent selection, and we also developed new methods that are based on cross-population comparisons to discover alleles that have swept to near-fixation within a population. The analysis reveals more than 300 strong candidate regions. Focusing on the strongest 22 regions, we develop a heuristic for scrutinizing these regions to identify candidate targets of selection. In a complementary analysis, we identify 26 non-synonymous, coding, single nucleotide polymorphisms showing regional evidence of positive selection. Examination of these candidates highlights three cases in which two genes in a common biological process have apparently undergone positive selection in the same population:LARGE and DMD, both related to infection by the Lassa virus, in West Africa;SLC24A5 and SLC45A2, both involved in skin pigmentation, in Europe; and EDAR and EDA2R, both involved in development of hair follicles, in Asia.

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Topics: International HapMap Project (57%), Natural selection (55%), Human genetic variation (55%) ... show more

1,573 Citations

Open accessJournal ArticleDOI: 10.1038/NATURE11413
Guofan Zhang1, Xiaodong Fang, Ximing Guo2, Li Li  +81 moreInstitutions (9)
04 Oct 2012-Nature
Abstract: The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly explored phyla, the Mollusca. Here we report the sequencing and assembly of the oyster genome using short reads and a fosmid-pooling strategy, along with transcriptomes of development and stress response and the proteome of the shell. The oyster genome is highly polymorphic and rich in repetitive sequences, with some transposable elements still actively shaping variation. Transcriptome studies reveal an extensive set of genes responding to environmental stress. The expansion of genes coding for heat shock protein 70 and inhibitors of apoptosis is probably central to the oyster's adaptation to sessile life in the highly stressful intertidal zone. Our analyses also show that shell formation in molluscs is more complex than currently understood and involves extensive participation of cells and their exosomes. The oyster genome sequence fills a void in our understanding of the Lophotrochozoa.

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Topics: Pacific oyster (64%), Oyster (62%), Genome (53%) ... show more

1,560 Citations

Open accessJournal ArticleDOI: 10.1038/NG.568
Anna Köttgen1, Anna Köttgen2, Cristian Pattaro3, Carsten A. Böger4  +134 moreInstitutions (41)
01 May 2010-Nature Genetics
Abstract: Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

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Topics: Kidney disease (62%), Renal function (59%), Cystatin C (54%) ... show more

692 Citations

Cited by

53,992 results found

Open access
28 Jul 2005-
Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1(PfPMP1)与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员,通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

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18,940 Citations

Open accessJournal ArticleDOI: 10.1016/J.JACC.2013.05.019
Clyde W. Yancy, Mariell Jessup, Biykem Bozkurt, Javed Butler  +20 moreInstitutions (4)
Abstract: Jeffrey L. Anderson, MD, FACC, FAHA, Chair; Alice K. Jacobs, MD, FACC, FAHA, Immediate Past Chair[‡‡][1]; Jonathan L. Halperin, MD, FACC, FAHA, Chair-Elect; Nancy M. Albert, PhD, CCNS, CCRN, FAHA; Biykem Bozkurt, MD, PhD, FACC, FAHA; Ralph G. Brindis, MD, MPH, MACC; Mark A. Creager, MD, FACC,

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10,622 Citations

No. of papers from the Author in previous years

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Author's top 5 most impactful journals


83 papers, 1.9K citations

Chinese Medical Journal

61 papers, 520 citations

Scientific Reports

59 papers, 3.9K citations


43 papers, 399 citations

National Medical Journal of China

26 papers, 61 citations

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