Wei Xie

TL;DR: The authors present small-molecule inhibitors of human cGAS, characterize their interaction with the protein, and show that the compounds are active in interferon-producing cells including primary human macrophages.

TL;DR: Factors that contribute to the enzymatic activity of the cGAS–cGAMP–STING pathway, a sentinel platform that senses the presence of foreign or mislocalized DNA in the cytoplasm, triggering innate immunity and interferon production are addressed.

TL;DR: The crystal structure, together with biochemical assays, reveals that the interdomain connecting loops of hRad9, hHus1, and hRad1 are largely divergent, and further cocrystallization study indicates that a PCNA-interacting box (PIP box)-containing peptide derived from hFen1 binds tightly to the inter domain connecting loop of h Rad1, providing the molecular basis for the damage repair-specific activity of the 9-1-1 complex in

TL;DR: This paper found that YTHDC1 is the essential reader in myeloid leukemia from a genome-wide CRISPR screen and that m6A is required for YTHdc1 to undergo liquid-liquid phase separation and form nuclear YTH DC1-m6A condensates (nYACs).

TL;DR: This study finds that the small molecule Ro 08–2750 (Ro) binds directly and selectively to MSI2 and competes for its RNA binding in biochemical assays and provides a framework for targeting RNA binding proteins in cancer.