Wei Yu

TL;DR: A massive anchored parallel sequencing method using next-generation sequencing to isolate and sequence HBV integrants and identified 8 genes that were recurrent target genes by HBV integration, suggesting a clonal expansion model in HCC development.

TL;DR: It is shown that knockdown of the SOX2 gene in LN229 GBM cells reduces cell proliferation and colony formation, and thatSOX2 down regulates BEX1 and BEX2, two genes with tumor suppressor activity in GBM, potentially creating a bistable system in G BM cells.

TL;DR: This study represents the most comprehensive characterization of HBV-related HCC transcriptome including exon level expression changes and novel splicing variants, which illustrated the power of RNA-seq and provided important clues for understanding the molecular mechanisms of HCC pathogenesis at system-wide levels.

TL;DR: It is suggested that the SOX2-FN1 axis is a key pathway in mediating the migration and invasion of ovarian cancer cells, and offers crucial molecular insights and promises to develop putative candidate therapeutic interventions in women with ovarian cancer.

TL;DR: An integrated expression profiling and ChIP-seq analysis show that SOX2 is involved in the BMP signaling pathway, steroid metabolic process, histone modifications, and many receptor-mediated signaling pathways such as IGF1R and ITPR2 (Inositol 1,4,5-triphosphate receptor, type 2).