Wei Yuan

TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.

TL;DR: It is reported that most skin-infiltrating lymphocytes in patients suffering from psoriasis, atopic or allergic-contact dermatitis express CCR10, indicating that CCL27–CCR10 interactions have a pivotal role in T cell–mediated skin inflammation.

TL;DR: In this paper , the role of exosomes derived from RBP-Joverexpressed macrophages (RBP-J OE Mφ-Exos) in glioma was investigated.

TL;DR: It is demonstrated that β2-microglobulin (B2M), a subunit of the class I major histocompatibility complex (MHC-I), promotes maintenance of stem-like neoplastic populations and reprograms the tumor immune microenvironment to an anti-inflammatory, tumor-promoting state and suggests that targeting B2M or its downstream axis may provide an effective approach for treating GBM.

TL;DR: Data indicate that WZY-321 triggers glioma cell apoptosis via XAF1 up-regulation caused by MTM-mediated miR-873 down-regulation.