Wei Zheng

TL;DR: Results indicate that macrophage-derived VEGF-C activates VEGFR-3 in tip cells to reinforce Notch signalling, which contributes to the phenotypic conversion of endothelial cells at fusion points of vessel sprouts.

TL;DR: Advances during the past decade have dramatically increased the knowledge of the mechanisms of lymphangiogenesis, including the roles of transcription factors,ymphangiogenic growth factors and their receptors, and intercellular and intracellular signaling cascades.

TL;DR: The largest meta-analysis of ER-negative disease to date, comprising 4754 ER- negative cases and 31 663 controls from three GWAS, identified two novel loci for breast cancer at 20q11 and 6q14 and confirmed three known loci associated with ER- Negative, triple negative and ER-positive breast cancer.

TL;DR: It is shown here that VEGF‐C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine, which could be especially important in the dietary regulation of adiposity and cholesterol metabolism.

TL;DR: It is shown that combined use of antibodies blocking ligand binding and receptor dimerization improves VEGFR inhibition and results in stronger inhibition of endothelial sprouting and vascular network formation in vivo, suggesting that receptor Dimerization inhibitors could be used to enhance antiangiogenic activity of antibodiesblocking ligandbinding in tumor therapy.