Wei Zhu

TL;DR: Compounds Currently in Phase II−III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas is presented.

TL;DR: 3D hydrogel-based triculture model that embeds hiPSC-HPCs with human umbilical vein endothelial cells and adipose-derived stem cells in a microscale hexagonal architecture is presented and finds improved morphological organization, higher liver-specific gene expression levels, increased metabolic product secretion, and enhanced cytochrome P450 induction.

TL;DR: The prevailing 3D printing techniques and their most recent applications in building tissue constructs are discussed and 3D bioprinting of vasculature network is particularly discussed for its foremost significance in maintaining tissue viability and promoting functional maturation.

TL;DR: It is found that injured host axons regenerate into 3D biomimetic scaffolds and synapse onto NPCs implanted into the device and that implanted NPCs in turn extend axons out of the scaffold and into the host spinal cord below the injury to restore synaptic transmission and significantly improve functional outcomes.

TL;DR: This work created prevascularized tissues with complex three-dimensional (3D) microarchitectures using a rapid biop printing method - microscale continuous optical bioprinting (μCOB) that can be broadly applicable to the engineering and translation of various functional tissues.