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Weidong Le

Researcher at Dalian Medical University

Publications -  321
Citations -  26099

Weidong Le is an academic researcher from Dalian Medical University. The author has contributed to research in topics: Parkinson's disease & Neuroprotection. The author has an hindex of 74, co-authored 287 publications receiving 22551 citations. Previous affiliations of Weidong Le include Ruijin Hospital & Baylor College of Medicine.

Papers
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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Daniel J. Klionsky, +235 more
- 16 Feb 2008 - 
TL;DR: A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
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Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

Yu Tang, +1 more
- 01 Mar 2016 - 
TL;DR: The changes of microglial phenotypes depend on the disease stages and severity; mastering the stage-specific switching of M1/M2 phenotypes within appropriate time windows may provide better therapeutic benefit.
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The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease.

Tianhong Pan, +3 more
- 01 Aug 2008 - 
TL;DR: The demonstration that alpha-synuclein is degraded by both proteasome and autophagy indicates a possible linkage between the dysfunction of the UPS or ALP and the occurrence of Parkinson's disease.
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Mutations in NR4A2 associated with familial Parkinson disease.

Weidong Le, +6 more
- 01 Jan 2003 - 
TL;DR: In this paper, two mutations in NR4A2 associated with Parkinson disease (−291Tdel and −245T→G) were identified, which map to the first exon and affect one allele in 10 of 107 individuals with familial Parkinson disease but not in any individuals with sporadic Parkinson disease or in unaffected controls.