Weil R. Lai

TL;DR: 11 different algorithms for analyzing array CGH data are compared, based on diverse techniques such as mixture models, Hidden Markov Models, maximum likelihood, regression, wavelets and genetic algorithms, to reveal general characteristics that are helpful to the biological investigator.

TL;DR: It is proposed that the MSL complex recognizes most X-linked genes, but only in the context of chromatin factors or modifications indicative of active transcription, which is likely to be an important function common to many chromatin organizing and modifying activities.

TL;DR: This work identified two sets of genes, associated with insulin signaling and a network of nuclear receptors, which are recurrent in a statistically significant number of diabetes and insulin resistance models and transcriptionally altered across diverse tissue types and additionally identified anetwork of protein–protein interactions between members from the two gene sets that may facilitate signaling between them.

TL;DR: Assessment of histone H3 lysine 4 dimethylation and trimethylation on a genome-wide scale in erythroid development reveals distinct epigenetic regulation of CGI and non-CGI genes during development and indicates an interactive relationship between DNA sequence and differential H3K4 methylation in lineage-specific differentiation.

TL;DR: The gene expression signature discovered in this study may represent a true "CNS signature" because it contrasted PCNSL with wide-spectrum non-CNS DLBCL on a genomic scale and performed an in-depth bioinformatic analysis.