Weizhe Lu

TL;DR: Comparisons of the comprehensive transcriptome of MEFs derived from two sexes suggest an importance of KDM5D-mediated demethylation of H3K4 involved in the sexually dimorphic gene expression in male MEFs, and may provide information regarding sex-dependent changes in gene expression when MEFs are used for experiments.

TL;DR: It is reported that juvenile cardiomyocyte-specific PRMT1-deficient mice develop severe dilatedCardiomyopathy and exhibit aberrant cardiac alternative splicing and it is revealed that eIF4A2 protein isoforms translated from alternatively spliced mRNA were differentially ubiquitinated and degraded by the ubiquitin-proteasome system.

TL;DR: It is found that histamine is elevated in the plasma of a preclinical mouse model with severe cardiac dysfunction and showed that it acts protectively rather than harmfully on heart and kidney damages in this model, and that a histamine H3 agonist, Imm, prevents the cardiorenal damages.

TL;DR: The results indicate that PRMT1 loss in the neural stem cell lineage causes disruptive changes in all glial types perturbing postnatal brain development and myelination.

TL;DR: The results suggest that Hsp70/CHIP chaperone-mediated protein degradation system is crucial in the regulation of PRMT5-v2 turnover, which has the potential to balance the symmetrical arginine dimethylation in cells.