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Wen-Ning Zhao
Researcher at Harvard University
Publications - 44
Citations - 5063
Wen-Ning Zhao is an academic researcher from Harvard University. The author has contributed to research in topics: Histone deacetylase & Wnt signaling pathway. The author has an hindex of 20, co-authored 40 publications receiving 3444 citations. Previous affiliations of Wen-Ning Zhao include Broad Institute & University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Aravind Subramanian,Rajiv Narayan,Steven M. Corsello,Steven M. Corsello,David Peck,Ted Natoli,Xiaodong Lu,Joshua Gould,John F. Davis,Andrew A. Tubelli,Jacob K. Asiedu,David L. Lahr,Jodi E. Hirschman,Zihan Liu,Melanie Donahue,Bina Julian,Mariya Khan,David Wadden,Ian Smith,Daniel D. Lam,Arthur Liberzon,Courtney Toder,Mukta Bagul,Marek Orzechowski,Oana M. Enache,Federica Piccioni,Sarah A. Johnson,Nicholas J. Lyons,Alice H. Berger,Alice H. Berger,Alykhan F. Shamji,Angela N. Brooks,Angela N. Brooks,Anita Vrcic,Corey Flynn,Jacqueline Rosains,David Y. Takeda,David Y. Takeda,Roger Hu,Desiree Davison,Justin Lamb,Kristin Ardlie,Larson Hogstrom,Peyton Greenside,Nathanael S. Gray,Nathanael S. Gray,Paul A. Clemons,Serena J. Silver,Xiaoyun Wu,Wen-Ning Zhao,Wen-Ning Zhao,Willis Read-Button,Xiaohua Wu,Stephen J. Haggarty,Stephen J. Haggarty,Lucienne Ronco,Jesse S. Boehm,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber,John G. Doench,Joshua A. Bittker,David E. Root,Bang Wong,Todd R. Golub +64 more
TL;DR: The expanded CMap is reported, made possible by a new, low-cost, high-throughput reduced representation expression profiling method that is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.
Journal ArticleDOI
Brain-Specific Phosphorylation of MeCP2 Regulates Activity-Dependent Bdnf Transcription, Dendritic Growth, and Spine Maturation
Zhaolan Zhou,Zhaolan Zhou,Elizabeth J. Hong,Elizabeth J. Hong,Sonia Cohen,Sonia Cohen,Wen-Ning Zhao,Hsin-Yi Henry Ho,Hsin-Yi Henry Ho,Lauren Schmidt,Wen G. Chen,Wen G. Chen,Yingxi Lin,Yingxi Lin,Erin M. Savner,Eric C. Griffith,Eric C. Griffith,Linda Hu,Judith A. Steen,Charles J. Weitz,Michael E. Greenberg,Michael E. Greenberg +21 more
TL;DR: It is shown that neuronal activity and subsequent calcium influx trigger the de novo phosphorylation of MeCP2 at serine 421 (S421) by a CaMKII-dependent mechanism, which controls the ability of Me CP2 to regulate dendritic patterning, spine morphogenesis, and the activity-dependent induction of Bdnf transcription.
Posted ContentDOI
A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles
Aravind Subramanian,Rajiv Narayan,Steven M. Corsello,David Peck,Ted Natoli,Xiaodong Lu,Joshua Gould,John F. Davis,Andrew A. Tubelli,Jacob K. Asiedu,David L. Lahr,Jodi E. Hirschman,Zihan Liu,Melanie Donahue,Bina Julian,Mariya Khan,David Wadden,Ian Smith,Daniel D. Lam,Arthur Liberzon,Courtney Toder,Mukta Bagul,Marek Orzechowski,Oana M. Enache,Federica Piccioni,Alice H. Berger,Alykhan F. Shamji,Angela N. Brooks,Anita Vrcic,Corey Flynn,Jacqueline Rosains,David Y. Takeda,Desiree Davison,Justin Lamb,Kristin Ardlie,Larson Hogstrom,Nathanael S. Gray,Paul A. Clemons,Serena J. Silver,Xiaoyun Wu,Wen-Ning Zhao,Willis Read-Button,Xiaohua Wu,Stephen J. Haggarty,Lucienne Ronco,Jesse S. Boehm,Stuart L. Schreiber,John G. Doench,Joshua A. Bittker,David E. Root,Bang Wong,Todd R. Golub +51 more
TL;DR: A new, low-cost, high throughput reduced representation expression profiling method, L1000, is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.
Journal ArticleDOI
An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors
Lisa A. Marcaurelle,Eamon Comer,Sivaraman Dandapani,Jeremy R. Duvall,Baudouin Gerard,Sarathy Kesavan,Maurice D. Lee,Haibo Liu,Jason T. Lowe,Jean-Charles Marie,Carol Mulrooney,Bhaumik A. Pandya,Ann Rowley,Troy D. Ryba,Byung-Chul Suh,Jingqiang Wei,Damian W. Young,Lakshmi B. Akella,Nathan T. Ross,Yan-Ling Zhang,Daniel M. Fass,Surya A. Reis,Wen-Ning Zhao,Stephen J. Haggarty,Michelle Palmer,Michael Foley +25 more
TL;DR: An aldol-based build/couple/pair (B/C/P) strategy was applied to generate a collection of stereochemically and skeletally diverse small molecules, leading to the discovery of a novel class of histone deacetylase inhibitors, and led to increased levels of acetylation in a primary mouse neuron culture.
Journal ArticleDOI
A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests.
Frederick A. Schroeder,Michael C. Lewis,Daniel M. Fass,Daniel M. Fass,Florence F. Wagner,Yan-Ling Zhang,Krista M. Hennig,Krista M. Hennig,Jennifer P. Gale,Wen-Ning Zhao,Surya A. Reis,Douglas Barker,Erin Berry-Scott,Sung Won Kim,Elizabeth L. Clore,Jacob M. Hooker,Jacob M. Hooker,Edward B. Holson,Stephen J. Haggarty,Tracey L. Petryshen,Tracey L. Petryshen +20 more
TL;DR: Evidence is provided that selective inhibition of HDAC1 and HDAC2 in brain may provide an epigenetic-based target for developing improved treatments for mood disorders and other brain disorders with altered chromatin-mediated neuroplasticity.