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Wendong Li
Researcher at City of Hope National Medical Center
Publications - 26
Citations - 3801
Wendong Li is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Neural stem cell & Induced pluripotent stem cell. The author has an hindex of 10, co-authored 18 publications receiving 3322 citations. Previous affiliations of Wendong Li include Chinese Academy of Sciences & Beckman Research Institute.
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Journal ArticleDOI
Bats are natural reservoirs of SARS-like coronaviruses.
Wendong Li,Zhengli Shi,Meng Yu,Wuze Ren,Craig Smith,Jonathan H. Epstein,Hanzhong Wang,Gary Crameri,Zhihong Hu,Huajun Zhang,Jianhong Zhang,Jennifer A. McEachern,Hume Field,Peter Daszak,Bryan T. Eaton,Shuyi Zhang,Lin-Fa Wang +16 more
TL;DR: It is reported that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS outbreak, and these viruses display greater genetic variation than SARS-CoV isolated from humans or from civets.
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MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling
TL;DR: Let-7b establishes an efficient strategy to control neural stem cell proliferation and differentiation by targeting the stem cell regulator TLX and the cell cycle regulator cyclin D1.
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miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells
Guoqiang Sun,Peng Ye,Kiyohito Murai,Ming-Fei Lang,Shengxiu Li,Heying Zhang,Wendong Li,Chelsea Fu,Jason Yin,Allen Wang,Xiaoxiao Ma,Yanhong Shi +11 more
TL;DR: It is shown that miR-137 has an essential role in controlling embryonic Neural stem cell fate determination and forms a feedback regulatory loop with TLX and LSD1 to control the dynamics between neural stem cell proliferation and differentiation during neural development.
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Histone Demethylase LSD1 Regulates Neural Stem Cell Proliferation
TL;DR: A novel role for LSD1 is revealed in neural stem cells proliferation and a mechanism for neural stem cell proliferation is uncovered through recruitment of LSD1 to modulate TLX activity is uncovered.
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Difference in Receptor Usage between Severe Acute Respiratory Syndrome (SARS) Coronavirus and SARS-Like Coronavirus of Bat Origin
Wuze Ren,Xiuxia Qu,Wendong Li,Zhenggang Han,Meng Yu,Peng Zhou,Shuyi Zhang,Lin-Fa Wang,Hongkui Deng,Zhengli Shi +9 more
TL;DR: This study investigated the receptor usage of the SL-CoV S by combining a human immunodeficiency virus-based pseudovirus system with cell lines expressing the ACE2 molecules of human, civet, or horseshoe bat, and found it to be largely compatible with SARS- coV S protein both in structure and in function.