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Wendy M. Mars
Researcher at University of Pittsburgh
Publications - 71
Citations - 6913
Wendy M. Mars is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Liver regeneration & Hepatocyte growth factor. The author has an hindex of 33, co-authored 67 publications receiving 6572 citations.
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Journal ArticleDOI
Bone marrow as a potential source of hepatic oval cells.
Bryon E. Petersen,W. C. Bowen,K. D. Patrene,Wendy M. Mars,A. K. Sullivan,N. Murase,S. S. Boggs,Joel S. Greenberger,Julie P. Goff +8 more
TL;DR: A stem cell associated with the bone marrow has epithelial cell lineage capability and a proportion of the regenerated hepatic cells were shown to be donor-derived.
Journal Article
Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA.
TL;DR: It is reported that both urokinase-type plasminogen activator and tissue-type Plasminogens activator can cleave single-chain hepatocyte growth factor, generating two- Chain hepatocytes growth factor.
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Hepatocyte growth factor/scatter factor is a motogen for interneurons migrating from the ventral to dorsal telencephalon.
TL;DR: The data suggest that HGF/SF motogenic activity, which is essential for normal development of other organ systems, is a conserved mechanism that regulates trans-telencephalic migration of interneurons.
Journal Article
Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes.
Satdarshan P.S. Monga,Wendy M. Mars,Peter Pediaditakis,Aaron Bell,Karen Mule,William C. Bowen,Xue Wang,Reza Zarnegar,George K. Michalopoulos +8 more
TL;DR: It is concluded that the HGF causes similar redistribution of β-catenin as Wnt-1 in the hepatocytes and that this effect is attributable to subcellular association of Met and β- catenin.
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Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy
Junwei Yang,Ryan W. Shultz,Wendy M. Mars,Rodney E. Wegner,Yingjian Li,Chunsun Dai,Kari Nejak,Youhua Liu +7 more
TL;DR: It is demonstrated that ablation of tPA attenuated renal interstitial fibrotic lesions in obstructive nephropathy and established a crucial and definite importance of EMT in the pathogenesis of renal interinterstitial fibrosis at the whole-animal level.