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Wenfei Sun
Researcher at ETH Zurich
Publications - 39
Citations - 1352
Wenfei Sun is an academic researcher from ETH Zurich. The author has contributed to research in topics: Adipose tissue & Brown adipose tissue. The author has an hindex of 11, co-authored 24 publications receiving 696 citations. Previous affiliations of Wenfei Sun include Columbia University & École Polytechnique Fédérale de Lausanne.
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Journal ArticleDOI
A stromal cell population that inhibits adipogenesis in mammalian fat depots
Petra C. Schwalie,Hua Dong,Magda Zachara,Julie Russeil,Daniel Alpern,Nassila Akchiche,Christian Caprara,Wenfei Sun,Kai-Uwe Schlaudraff,Gianni Soldati,Christian Wolfrum,Bart Deplancke +11 more
TL;DR: Single-cell transcriptomics reveals that, in mice and humans, a population of cells in the stromal vascular fraction of adipose tissue regulates adipogenesis by suppressing adipocyte formation in a paracrine manner.
Journal ArticleDOI
snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis.
Wenfei Sun,Hua Dong,Miroslav Balaz,Michal Slyper,Eugene Drokhlyansky,Georgia Colleluori,Antonio Giordano,Zuzana Kovanicova,Patrik Stefanicka,Lucia Balazova,Lianggong Ding,Anna Sofie Husted,Gottfried Rudofsky,Jozef Ukropec,Saverio Cinti,Thue W. Schwartz,Aviv Regev,Christian Wolfrum +17 more
TL;DR: A rare subpopulation of adipocytes in mice that increases in abundance at higher temperatures is identified, and it is shown that this subpopulation regulates the activity of neighbouring adipocytes through acetate-mediated modulation of their thermogenic capacity.
Journal ArticleDOI
Maternal overnutrition programs hedonic and metabolic phenotypes across generations through sperm tsRNAs.
Gitalee Sarker,Wenfei Sun,David Rosenkranz,Pawel Pelczar,Lennart Opitz,Vissarion Efthymiou,Christian Wolfrum,Daria Peleg-Raibstein +7 more
TL;DR: It is demonstrated that sperm tsRNA is a potential vector that contributes to the transmission of MHFD-induced addictive-like behaviors and obesogenic phenotypes across generations, thereby emphasizing its role in diverse pathological outcomes.
Journal ArticleDOI
Bmp4 Promotes a Brown to White-like Adipocyte Shift
Salvatore Modica,Leon G. Straub,Miroslav Balaz,Wenfei Sun,Lukas Varga,Patrik Stefanicka,Milan Profant,Eric Simon,Heike Neubauer,Barbara Ukropcova,Jozef Ukropec,Christian Wolfrum +11 more
TL;DR: It is proposed that Bmp4 is an important factor in the context of obesity and type 2 diabetes because of a strong correlation between BMP4 levels and adipocyte size, as well as insulin sensitivity in humans.
Journal ArticleDOI
Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring.
Wenfei Sun,Hua Dong,Anton S. Becker,Anton S. Becker,Dianne H. Dapito,Salvatore Modica,Gerald Grandl,Lennart Opitz,Lennart Opitz,Vissarion Efthymiou,Leon G. Straub,Gitalee Sarker,Miroslav Balaz,Lucia Balazova,Aliki Perdikari,Elke Kiehlmann,Sara Bacanovic,Caroline Zellweger,Daria Peleg-Raibstein,Pawel Pelczar,Wolf Reik,Wolf Reik,Irene A. Burger,Ferdinand von Meyenn,Ferdinand von Meyenn,Christian Wolfrum +25 more
TL;DR: It is shown retrospectively that the presence of brown adipose tissue (BAT) and the season of conception are linked to BMI in humans and in mice, and that cold exposure of males, but not females, before mating results in improved systemic metabolism and protection from diet-induced obesity of the male offspring.