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Wenhao Liu
Researcher at Massachusetts Institute of Technology
Publications - 37
Citations - 8495
Wenhao Liu is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Quantum dot & Photoluminescence. The author has an hindex of 19, co-authored 36 publications receiving 7834 citations. Previous affiliations of Wenhao Liu include Samsung & Beth Israel Deaconess Medical Center.
Papers
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Journal ArticleDOI
Renal clearance of quantum dots.
Hak Soo Choi,Wenhao Liu,Preeti Misra,Eiichi Tanaka,John P. Zimmer,Binil Itty Ipe,Moungi G. Bawendi,John V. Frangioni,John V. Frangioni +8 more
TL;DR: This study has precisely defined the requirements for renal filtration and urinary excretion of inorganic, metal-containing nanoparticles and provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications.
Journal ArticleDOI
Design considerations for tumour-targeted nanoparticles
Hak Soo Choi,Wenhao Liu,Fangbing Liu,Khaled Nasr,Preeti Misra,Moungi G. Bawendi,John V. Frangioni +6 more
TL;DR: This study shows that quantum dots functionalized with high-affinity small-molecule ligands that target tumours can also be cleared by the kidneys if their hydrodynamic diameter is less than this value, which sets an upper limit of 5-10 ligands per quantum dot for renal clearance.
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Compact Biocompatible Quantum Dots Functionalized for Cellular Imaging
Wenhao Liu,Mark Howarth,Andrew B. Greytak,Yi Zheng,Daniel G. Nocera,Alice Y. Ting,Moungi G. Bawendi +6 more
TL;DR: A family of water-soluble quantum dots (QDs) that exhibit low nonspecific binding to cells, small hydrodynamic diameter, tunable surface charge, high quantum yield, and good solution stability across a wide pH range are presented.
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Monovalent, reduced-size quantum dots for imaging receptors on living cells.
Mark Howarth,Mark Howarth,Wenhao Liu,Sujiet Puthenveetil,Yi Zheng,Lisa F. Marshall,Michael M. Schmidt,K. Dane Wittrup,Moungi G. Bawendi,Alice Y. Ting +9 more
TL;DR: In this paper, a method to generate monovalent quantum dots (QDs) using agarose gel electrophoresis was described, which improved access of QD-labeled glutamate receptors to neuronal synapses, and monovalency prevented EphA3 tyrosine kinase activation.
Journal ArticleDOI
Compact Cysteine-Coated CdSe(ZnCdS) Quantum Dots for in Vivo Applications
TL;DR: The ability to directly conjugate to QD-Cys opens up the possibility of functionalized nanocrystals for in vivo targeted imaging, in which small targeting molecules can be appended to QDs, and unbound QDs can be rapidly cleared to achieve high signal/noise ratios and to reduce background toxicity.