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Wenjie Tan
Researcher at Chinese Center for Disease Control and Prevention
Publications - 23
Citations - 10352
Wenjie Tan is an academic researcher from Chinese Center for Disease Control and Prevention. The author has contributed to research in topics: Cellular immunity & Vaccination. The author has an hindex of 11, co-authored 21 publications receiving 7836 citations. Previous affiliations of Wenjie Tan include Wenzhou Medical College & Chinese Academy of Sciences.
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells.
Na Zhu,Wenling Wang,Zhidong Liu,Chaoyang Liang,Wen Wang,Fei Ye,Baoying Huang,Li Zhao,Huijuan Wang,Weimin Zhou,Yao Deng,Longfei Mao,Chongyu Su,Guangliang Qiang,Taijiao Jiang,Jincun Zhao,Guizhen Wu,Jingdong Song,Wenjie Tan,Wenjie Tan +19 more
TL;DR: Replication of SARS-CoV-2 in human airway epithelial (HAE) cultures is characterized and it is shown that it can infect ciliated and secretory cells, affects transepithelial electrical resistance and causes plaque-like cytopathic effects associated with apoptosis.
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Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus Challenge
Jiaming Lan,Jiaming Lan,Yanfeng Yao,Yao Deng,Hong Chen,Guangwen Lu,Wen Wang,Linlin Bao,Wei Deng,Qiang Wei,George F. Gao,Chuan Qin,Wenjie Tan +12 more
TL;DR: Robust and sustained immunological responses (including neutralisation antibody) were elicited by the rRBD vaccination and this data in NHP paves a way for further development of an effective human vaccine against MERS-CoV infection.
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Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy
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Tailoring subunit vaccine immunity with adjuvant combinations and delivery routes using the Middle East respiratory coronavirus (MERS-CoV) receptor-binding domain as an antigen.
Jiaming Lan,Yao Deng,Hong Chen,Guangwen Lu,Wen Wang,Xiaojuan Guo,Zhuozhuang Lu,George F. Gao,Wenjie Tan +8 more
TL;DR: The vaccination regimen used in this study is promising and could improve the protection offered by the MERS-CoV subunit vaccine by eliciting effective humoral and cellular immune responses, and suggest that murine immunity following subunit vaccination can be tailored using adjuvant combinations and delivery routes.