Wenjing Xu

Bio: Wenjing Xu is an academic researcher. The author has an hindex of 1, co-authored 1 publications receiving 4 citations.

Efficient synthesis of N-arylsulfonyl-1,2,3-triazoles from 1,1-dibromo-2-arylethylenes

Abstract: Abstract N-arylsulfonyl-1,2,3-triazoles were synthesized from 1,1-dibromo-2-arylethylenes via a one-pot reaction involving the Cs2CO3-mediated dehydrobromination process of the dibromoalkenes to produce alkynes followed by the Cu(I)-catalyzed Huisgen cycloaddition of the alkyne intermediates with tosyl azide.

Tandem Suzuki—Miyaura Cross-Coupling/Dehydrobromination of 1,1-Dibromoalkenes to Alkynes with a Cyclobutene-1,2-diylbis(imidazolium) Salt as Catalyst Precursor.

Abstract: Dibromoalkenes, prepared from aldehydes under Corey—Fuchs conditions, undergo a tandem process in one pot to give the desired alkyne products within a short time.

Advances in the Synthesis of NH-1,2,3-Triazoles

Abstract: NH-1,2,3-Triazoles are a kind of N-containing heterocylic compounds with important biological activities, which have found broad use in medicinal intermediates. Besides, NH-1,2,3-triazoles serve as valuable synthetic intermediates for the preparation of 2-substituded-1,2,3-triazoles through N-alkylation re- action. Because of their potent applications in both synthetic organic chemistry and medicinal chemistry, the progess in the synthesis of NH-1,2,3-triazoles, especially those reported in the past decade, is surveyed ac- cording to the research by our group and other groups. Some classical reaction mechanics are also reviewed in this paper.

Synthesis, chemistry and uses of N-sulfonated N-triazoles and N-tetrazoles

Abstract: N-sulfonyl triazole is an intermediate in organic synthesis and has been proven to be an excellent nitrogen source for the construction of many heterocycles. Due to its more favorable pharmacokinetic properties, tetrazole has also been proven to be a suitable bioisostere derived from a carboxylic acid and cisamide units. This chapter summarizes the new and innovative synthetic strategies that have been developed for the synthesis and ring-opening of N-sulfonyl triazoles and tetrazoles. This chapter covers the chemistry of N-sulfonyl triazole and tetrazole and their applications in medicine and pharmaceuticals. Initially, we discussed various synthetic methods of N-sulfonyl-1,2,3-triazoles, and then how reactive N-sulfonyltriazole is sufficient to open the ring and form acyclic amine derivatives (β-phenethylamine, o-diamine, allylamine, enamine, and Ketimine) or other cyclic N-sulfonylamines. This chapter also introduces the synthesis and use of N-sulfonyl-1,2,3,4-tetrazole. We focused on the synthetic development for the production of N-sulfonyl triazole and tetrazole and their reaction types.

Synthesis of symmetrical 1, 3-diynes via tandem reaction of ( Z )-arylvinyl bromides in the presence of DBU and CuI

Abstract: Microwave-assisted tandem reaction of ( Z )-arylvinyl bromides involving an elimination and homocoupling in the presence of DBU and CuI in DMF affords a variety of symmetrical 1,3-diynes in good to excellent yields. This tandem process, eliminating the need of volatile and savory terminal alkynes, provides an alternative to the conventional homocoupling methods for the synthesis of symmetrical 1,3-diynes.