W
Werner Falk
Researcher at University of Regensburg
Publications - 179
Citations - 16095
Werner Falk is an academic researcher from University of Regensburg. The author has contributed to research in topics: Cytokine & Tumor necrosis factor alpha. The author has an hindex of 59, co-authored 179 publications receiving 15458 citations. Previous affiliations of Werner Falk include German Cancer Research Center & Heidelberg University.
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Journal ArticleDOI
Monoclonal antibody-mediated tumor regression by induction of apoptosis
B. C. Trauth,C. Klas,Anke M.J. Peters,Siegfried Matzku,Peter Möller,Werner Falk,Klaus-Michael Debatin,Peter H. Krammer +7 more
TL;DR: Histological thin sections of the regressing tumor showed that anti-APO-1 was able to induce apoptosis in vivo, suggesting induction of apoptosis as a consequence of a signal mediated through cell surface molecules like APO- 1 may be a useful therapeutic approach in treatment of malignancy.
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Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.
Lothar Steidler,Wolfgang Hans,Lieven Schotte,Sabine Neirynck,Florian Obermeier,Werner Falk,Walter Fiers,Erik Remaut +7 more
TL;DR: Using two mouse models, it is shown that the therapeutic dose of IL-10 can be reduced by localized delivery of a bacterium genetically engineered to secrete the cytokine.
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A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration
TL;DR: A 48-well chemotaxis chamber to minimize manipulation time and amount of material required by the larger blindwell or Boyden chemot axis chamber is designed, suitable for clinical research on the functional state of monocytes in large groups of patients.
Journal ArticleDOI
Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.
A. Oehm,Iris Behrmann,Werner Falk,Michael Pawlita,Gerhard Maier,C. Klas,Min Li-Weber,S. Richards,Jens Dhein,B. C. Trauth +9 more
TL;DR: The APO-1 antigen was expressed upon transfection of APo-1 cDNA into BL60-P7 Burkitt's lymphoma cells and conferred sensitivity towards anti-APO- 1-induced apoptosis to the transfectants.
Journal Article
Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis.
TL;DR: During the early phase of peritonitis endogenous TNF may stimulate nonlymphoid cells such as granulocytes, macrophages, platelets, and fibroblasts to ingest bacteria and to localize inflammation, respectively, which may determine survival.