Werner Stöber

Bio: Werner Stöber is an academic researcher from University of Rochester. The author has contributed to research in topics: Aerosol & Centrifuge. The author has an hindex of 6, co-authored 9 publications receiving 12034 citations. Previous affiliations of Werner Stöber include University of Vienna & University of Münster.

Preparation of radioactively labeled monodisperse silica spheres of colloidal size.

Abstract: A recently developed technique of growing monodisperse silica spheres of predetermined size in alcoholic solutions facilitates the incorporation of certain radioactive tracers. Spheres growing to a final diameter of 8 × 10 −5 cm were used in a study with radioactive isotopes including 7 Be, 51 Cr, 54 Mn, 58 Co, 59 Fe, 65 Zn, 124 Sb, 134 Cs, and 141 Ce. The results reveal that those metals which form oxides of low solubility at pH ≥ 7 are easily incorporated into the bulk of the silica spheres when present during the growth of the particles in an amount not exceeding 1–10 ppm with respect to the total mass of silica in the system.

Distribution analyses of the aerodynamic size and the mass of aerosol particles by means of the spiral centrifuge in comparison to other aerosol precipitators

Abstract: The spiral centrifuge, a new particle-size spectrometer for aerosols, facilitates the precipitation of aerosols in the size range from less than 8 × 10−6 to 6 × 10−4 cm in diameter. The particles are separated according to their aerodynamic diameter along a strip foil of 180 cm length. The calibration of the deposit strip in terms of aerodynamic diameters permits the determination of the size distribution by a count analysis. The mass distribution can be obtained by a gravimetric or, in case of a fluorescein test aerosol, by fluorometric analysis. Due to small irregularities of the deposition patterns, empirical corrections may apply to the experimental data. However, comparison of centrifuge results with data from other precipitators, as electrostatic and thermal devices or cascade impactors, indicates that for three fluorescein test aerosols practically no corrections were necessary because of the random nature of the deviations. The spiral centrifuge gives consistent results over the whole size range investigated. With the aerosol entrance employed, substantial particle losses to the entrance section seemed to occur above 2 × 10−4 cm.

Magnetic nanoparticles: Synthesis, protection, functionalization, and application

Abstract: This review focuses on the synthesis, protection, functionalization, and application of magnetic nanoparticles, as well as the magnetic properties of nanostructured systems. Substantial progress in the size and shape control of magnetic nanoparticles has been made by developing methods such as co-precipitation, thermal decomposition and/or reduction, micelle synthesis, and hydrothermal synthesis. A major challenge still is protection against corrosion, and therefore suitable protection strategies will be emphasized, for example, surfactant/polymer coating, silica coating and carbon coating of magnetic nanoparticles or embedding them in a matrix/support. Properly protected magnetic nanoparticles can be used as building blocks for the fabrication of various functional systems, and their application in catalysis and biotechnology will be briefly reviewed. Finally, some future trends and perspectives in these research areas will be outlined.

Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications

Abstract: 1. Introduction 20642. Synthesis of Magnetic Nanoparticles 20662.1. Classical Synthesis by Coprecipitation 20662.2. Reactions in Constrained Environments 20682.3. Hydrothermal and High-TemperatureReactions20692.4. Sol-Gel Reactions 20702.5. Polyol Methods 20712.6. Flow Injection Syntheses 20712.7. Electrochemical Methods 20712.8. Aerosol/Vapor Methods 20712.9. Sonolysis 20723. Stabilization of Magnetic Particles 20723.1. Monomeric Stabilizers 20723.1.1. Carboxylates 20733.1.2. Phosphates 20733.2. Inorganic Materials 20733.2.1. Silica 20733.2.2. Gold 20743.3. Polymer Stabilizers 20743.3.1. Dextran 20743.3.2. Polyethylene Glycol (PEG) 20753.3.3. Polyvinyl Alcohol (PVA) 20753.3.4. Alginate 20753.3.5. Chitosan 20753.3.6. Other Polymers 20753.4. Other Strategies for Stabilization 20764. Methods of Vectorization of the Particles 20765. Structural and Physicochemical Characterization 20785.1. Size, Polydispersity, Shape, and SurfaceCharacterization20795.2. Structure of Ferro- or FerrimagneticNanoparticles20805.2.1. Ferro- and Ferrimagnetic Nanoparticles 20805.3. Use of Nanoparticles as Contrast Agents forMRI20825.3.1. High Anisotropy Model 20845.3.2. Small Crystal and Low Anisotropy EnergyLimit20855.3.3. Practical Interests of Magnetic NuclearRelaxation for the Characterization ofSuperparamagnetic Colloid20855.3.4. Relaxation of Agglomerated Systems 20856. Applications 20866.1. MRI: Cellular Labeling, Molecular Imaging(Inflammation, Apoptose, etc.)20866.2.

Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance

Abstract: Metal nanoshells are a class of nanoparticles with tunable optical resonances. In this article, an application of this technology to thermal ablative therapy for cancer is described. By tuning the nanoshells to strongly absorb light in the near infrared, where optical transmission through tissue is optimal, a distribution of nanoshells at depth in tissue can be used to deliver a therapeutic dose of heat by using moderately low exposures of extracorporeally applied near-infrared (NIR) light. Human breast carcinoma cells incubated with nanoshells in vitro were found to have undergone photothermally induced morbidity on exposure to NIR light (820 nm, 35 W/cm2), as determined by using a fluorescent viability stain. Cells without nanoshells displayed no loss in viability after the same periods and conditions of NIR illumination. Likewise, in vivo studies under magnetic resonance guidance revealed that exposure to low doses of NIR light (820 nm, 4 W/cm2) in solid tumors treated with metal nanoshells reached average maximum temperatures capable of inducing irreversible tissue damage (DeltaT = 37.4 +/- 6.6 degrees C) within 4-6 min. Controls treated without nanoshells demonstrated significantly lower average temperatures on exposure to NIR light (DeltaT < 10 degrees C). These findings demonstrated good correlation with histological findings. Tissues heated above the thermal damage threshold displayed coagulation, cell shrinkage, and loss of nuclear staining, which are indicators of irreversible thermal damage. Control tissues appeared undamaged.

A hybridization model for the plasmon response of complex nanostructures.

Abstract: We present a simple and intuitive picture, an electromagnetic analog of molecular orbital theory, that describes the plasmon response of complex nanostructures of arbitrary shape. Our model can be understood as the interaction or "hybridization" of elementary plasmons supported by nanostructures of elementary geometries. As an example, the approach is applied to the important case of a four-layer concentric nanoshell, where the hybridization of the plasmons of the inner and outer nanoshells determines the resonant frequencies of the multilayer nanostructure.