William A. Sibley

TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.

TL;DR: The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.

TL;DR: Frequency of common infections was approximately 20-50% less in MS patients than controls; it was progressively less in those with greater disability, suggesting that MS patients could have superior immune defences against common viruses.

TL;DR: This preliminary report, based on observations of the first 135 cases entered, demonstrates that adequate randomization of patients can be obtained in this disease and describes means for reasonably accurate evaluation of the many clinical changes seen in multiple sclerosis patients under treatment.