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William B. Applegate
Researcher at Wake Forest University
Publications - 211
Citations - 20566
William B. Applegate is an academic researcher from Wake Forest University. The author has contributed to research in topics: Blood pressure & Randomized controlled trial. The author has an hindex of 62, co-authored 208 publications receiving 19654 citations. Previous affiliations of William B. Applegate include University of Tennessee & University of Tennessee Health Science Center.
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Journal ArticleDOI
Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial.
Steven R. Cummings,Dennis M. Black,Desmond E. Thompson,William B. Applegate,Elizabeth Barrett-Connor,Thomas Musliner,Lisa Palermo,Ronald J. Prineas,Susan M. Rubin,Jean Scott,Thomas M. Vogt,Robert B. Wallace,A. John Yates,Andrea Z. LaCroix +13 more
TL;DR: In women with low BMD but without vertebral fractures, 4 years of alendronate safely increased BMD and decreased the risk of first vertebral deformity.
Journal ArticleDOI
A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial (FAST)
Walter H. Ettinger,Robert Burns,Stephen P. Messier,William B. Applegate,W. Jack Rejeski,Timothy R. Morgan,Sally A. Shumaker,Michael J. Berry,Mary L. O'Toole,Johnny U. V. Monu,Timothy E. Craven +10 more
TL;DR: The data suggest that exercise should be prescribed as part of the treatment for knee osteoarthritis, and modest improvements in measures of disability, physical performance, and pain from participating in either an aerobic or a resistance exercise program.
Journal ArticleDOI
Sodium Reduction and Weight Loss in the Treatment of Hypertension in Older Persons: A Randomized Controlled Trial of Nonpharmacologic Interventions in the Elderly (TONE)
Paul K. Whelton,Lawrence J. Appel,Mark A. Espeland,William B. Applegate,Walter H. Ettinger,John B. Kostis,Shiriki K. Kumanyika,Shiriki K. Kumanyika,Clifton R. Lacy,Karen C. Johnson,Steven Folmar,Jeffrey A. Cutler +11 more
TL;DR: Reduced sodium intake and weight loss constitute a feasible, effective, and safe nonpharmacologic therapy of hypertension in older persons.
Journal ArticleDOI
Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial.
Jeff D. Williamson,Mark A. Supiano,Mark A. Supiano,William B. Applegate,Dan R. Berlowitz,Dan R. Berlowitz,Ruth C. Campbell,Glenn M. Chertow,Larry J. Fine,William E. Haley,Amret T. Hawfield,Joachim H. Ix,Joachim H. Ix,Dalane W. Kitzman,John B. Kostis,Marie Krousel-Wood,Lenore J. Launer,Suzanne Oparil,Carlos J. Rodriguez,Christianne L. Roumie,Christianne L. Roumie,Ronald I. Shorr,Ronald I. Shorr,Kaycee M. Sink,Virginia G. Wadley,Paul K. Whelton,Jeff Whittle,Jeff Whittle,Nancy Woolard,Jackson T. Wright,Nicholas M. Pajewski +30 more
TL;DR: Among ambulatory adults aged 75 years or older, treating to an SBP target of less than 120 mm Hg compared with an SBp target of more than 140mm Hg resulted in significantly lower rates of fatal and nonfatal major cardiovascular events and death from any cause.
Journal ArticleDOI
Effect of Diuretic-Based Antihypertensive Treatment on Cardiovascular Disease Risk in Older Diabetic Patients With Isolated Systolic Hypertension
J. David Curb,Sara L. Pressel,Jeffrey A. Cutler,Peter J. Savage,William B. Applegate,Henry R. Black,Greta Camel,Barry R. Davis,P. Frost,Nelly Gonzalez,Gordon P. Guthrie,Albert Oberman,Gail H. Rutan,Jeremiah Stamler +13 more
TL;DR: Low-dose diuretic-based (chlorthalidone) treatment is effective in preventing major CVD events, cerebral and cardiac, in both non-insulin-treated diabetic and nondiabetic older patients with ISH.