W
William C. Duckworth
Researcher at United States Department of Veterans Affairs
Publications - 152
Citations - 14797
William C. Duckworth is an academic researcher from United States Department of Veterans Affairs. The author has contributed to research in topics: Insulin & Diabetes mellitus. The author has an hindex of 48, co-authored 152 publications receiving 13896 citations. Previous affiliations of William C. Duckworth include Indiana University – Purdue University Indianapolis & University of Arizona.
Papers
More filters
Journal ArticleDOI
Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes
William C. Duckworth,Carlos Abraira,Thomas E. Moritz,Domenic J. Reda,Nicholas V. Emanuele,Peter D. Reaven,Franklin J. Zieve,Jennifer B. Marks,Stephen N. Davis,Rodney A. Hayward,Stuart R. Warren,Steven Goldman,Madeline McCarren,Mary Ellen Vitek,William G. Henderson,Grant D. Huang +15 more
TL;DR: Intensive glucose control in patients with poorly controlled type 2 diabetes had no significant effect on the rates of major cardiovascular events, death, or microvascular complications with the exception of progression of albuminuria.
Journal ArticleDOI
Intensive glucose control and macrovascular outcomes in type 2 diabetes
Fiona Turnbull,Carlos Abraira,Robert J. Anderson,Robert J. Anderson,Robert P. Byington,John Chalmers,William C. Duckworth,Gregory W. Evans,Hertzel C. Gerstein,Rury R. Holman,Thomas E. Moritz,Bruce Neal,Toshiharu Ninomiya,Anushka Patel,Sanjoy K. Paul,F. Travert,Mark Woodward,Mark Woodward +17 more
TL;DR: Targeting more-intensive glucose lowering modestly reduced major macrovascular events and increased major hypoglycaemia over 4.4 years in persons with type 2 diabetes, and suggests that glucose-lowering regimens should be tailored to the individual.
Journal ArticleDOI
Combined Angiotensin Inhibition for the Treatment of Diabetic Nephropathy
Linda F. Fried,Nicholas V. Emanuele,Nicholas V. Emanuele,Jane H. Zhang,Mary Brophy,Todd A. Conner,William C. Duckworth,William C. Duckworth,David J. Leehey,David J. Leehey,Peter A. McCullough,Theresa Z. O'Connor,Paul M. Palevsky,Robert F. Reilly,Stephen L. Seliger,Stuart R. Warren,Suzanne Watnick,Peter Peduzzi,Peter Peduzzi,Peter Guarino +19 more
TL;DR: Combination therapy with an ACE inhibitor and an ARB was associated with an increased risk of adverse events among patients with diabetic nephropathy and safety outcomes included mortality, hyperkalemia, and acute kidney injury.
Journal ArticleDOI
Insulin Degradation: Progress and Potential
TL;DR: Insulin degradation is a regulated process that plays a role in controlling insulin action by removing and inactivating the hormone, and the possibility of a direct intracellular interaction of insulin with IDE that could modulate protein and fat metabolism is raised.
Journal ArticleDOI
Follow-up of Glycemic Control and Cardiovascular Outcomes in Type 2 Diabetes
Rodney A. Hayward,Peter D. Reaven,Wyndy L. Wiitala,Gideon Bahn,Domenic J. Reda,Ling Ge,Madeline McCarren,William C. Duckworth,Nicholas V. Emanuele +8 more
TL;DR: Patients with type 2 diabetes who had been randomly assigned to intensive glucose control for 5.6 years had 8.6 fewer major cardiovascular events per 1000 person-years than those assigned to standard therapy, but no improvement was seen in the rate of overall survival.