W
William C. Reinhold
Researcher at National Institutes of Health
Publications - 118
Citations - 12066
William C. Reinhold is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 47, co-authored 112 publications receiving 10922 citations. Previous affiliations of William C. Reinhold include Georgia Institute of Technology & University of Genoa.
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Journal ArticleDOI
A gene expression database for the molecular pharmacology of cancer
Uwe Scherf,Douglas T. Ross,Mark Waltham,Lawrence H. Smith,Jae K. Lee,Lorraine K. Tanabe,Kurt W. Kohn,William C. Reinhold,Timothy G. Myers,Darren T. Andrews,Dominic A. Scudiero,Michael B. Eisen,Edward A. Sausville,Yves Pommier,David Botstein,Patrick O. Brown,John N. Weinstein +16 more
TL;DR: Gene-drug relationships for the clinical agents 5-fluorouracil and L-asparaginase exemplify how variations in the transcript levels of particular genes relate to mechanisms of drug sensitivity and resistance.
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GoMiner: a resource for biological interpretation of genomic and proteomic data
Barry R. Zeeberg,Weimin Feng,Geoffrey D. Wang,May D. Wang,Anthony T. Fojo,Margot Sunshine,Sudarshan Narasimhan,David W. Kane,William C. Reinhold,Samir Lababidi,Kimberly J. Bussey,Joseph Riss,J. Carl Barrett,John N. Weinstein +13 more
TL;DR: GoMiner, a program package that organizes lists of 'interesting' genes for biological interpretation in the context of the Gene Ontology, provides quantitative and statistical output files and two useful visualizations.
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CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set
William C. Reinhold,Margot Sunshine,Margot Sunshine,Hongfang Liu,Sudhir Varma,Kurt W. Kohn,Joel Morris,James H. Doroshow,Yves Pommier +8 more
TL;DR: A CellMiner web application is introduced designed to improve the use of the extensive NCI-60 cell line database for discovery by creating web-based processes that are rapid, flexible, and readily applied by users without bioinformatics expertise.
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Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells
Gergely Szakács,Jean Philippe Annereau,Samir Lababidi,Uma Shankavaram,Angela Arciello,Kimberly J. Bussey,William C. Reinhold,Yanping Guo,Gary D. Kruh,Mark Reimers,John N. Weinstein,Michael M. Gottesman +11 more
TL;DR: This work profiled mRNA expression of the 48 known human ABC transporters in 60 diverse cancer cell lines used by the National Cancer Institute and found and validated compounds whose activity is potentiated, rather than antagonized, by the MDR1 multidrug transporter.
Journal ArticleDOI
Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms.
R A Berkman,Marsha J. Merrill,William C. Reinhold,William T. Monacci,Abha Saxena,W C Clark,James T. Robertson,Iqbal Unnisa Ali,Edward H. Oldfield +8 more
TL;DR: A significant role for VEGPF is suggested in the development of CNS tumor neovascularity and peritumoral edema and in capillary hemangioblastomas.