W
William C. Rose
Researcher at Yale University
Publications - 6
Citations - 455
William C. Rose is an academic researcher from Yale University. The author has contributed to research in topics: Creatine & Creatinine. The author has an hindex of 5, co-authored 6 publications receiving 438 citations.
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Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity
Rick Avery Finch,M.‐C. Liu,Susan P. Grill,William C. Rose,Regina Loomis,Karen M. Vasquez,Yung-Chi Cheng,Alan C. Sartorelli +7 more
TL;DR: The findings demonstrate the superiority of Triapine over hydroxyurea as an anticancer agent and suggest that prevention byTriapine of repair of DNA lesions created by agents that damage DNA may result in efficacious drug combinations for the treatment of cancer.
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Antitumor 2-(aminocarbonyl)-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)- hydrazines.
TL;DR: Several 2-(aminocarbonyl-1,2-bis(methylsulfonyl)-1-(2-chloroethyl- 2(-)[[2- chloroethyl)-amino]carbonyl]hydrazine compounds were synthesized and evaluated for antitumor activity against the murine L1210 leukemia, findingounced activity was found against all of the tumors.
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