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William G. Herrington
Researcher at Clinical Trial Service Unit
Publications - 127
Citations - 7206
William G. Herrington is an academic researcher from Clinical Trial Service Unit. The author has contributed to research in topics: Kidney disease & Medicine. The author has an hindex of 28, co-authored 100 publications receiving 5153 citations. Previous affiliations of William G. Herrington include University of Oxford & Churchill Hospital.
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Journal ArticleDOI
The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial
Colin Baigent,Martin J Landray,Christina Reith,Jonathan Emberson,David C. Wheeler,Charles R.V. Tomson,Christoph Wanner,Vera Krane,Alan Cass,Jonathan C. Craig,Bruce Neal,Lixin Jiang,Lai Seong Hooi,Adeera Levin,Lawrence Y. Agodoa,Mike Gaziano,Bertram L. Kasiske,Robert J. Walker,Ziad A. Massy,Bo Feldt-Rasmussen,Udom Krairittichai,Vuddidhej Ophascharoensuk,Bengt Fellström,Hallvard Holdaas,Vladimir Tesar,Andrzej Wiecek,Diederick E. Grobbee,Dick de Zeeuw,Carola Grönhagen-Riska,Tanaji Dasgupta,David Lewis,William G. Herrington,Marion Mafham,William Majoni,K Wallendszus,Richard H. Grimm,Terje R. Pedersen,Jonathan A. Tobert,Jane Armitage,Alex Baxter,Christopher Bray,Yiping Chen,Zhengming Chen,Michael Hill,Carol Knott,Sarah Parish,David Simpson,Peter Sleight,Alan Young,Rory Collins +49 more
TL;DR: Reduction of LDL cholesterol with simvastatin 20 mg plus ezetimibe 10 mg daily safely reduced the incidence of major atherosclerotic events in a wide range of patients with advanced chronic kidney disease.
Journal ArticleDOI
Epidemiology of Atherosclerosis and the Potential to Reduce the Global Burden of Atherothrombotic Disease
TL;DR: Widespread changes in health behaviors and use of treatments for these risk factors are responsible for some of the dramatic declines in vascular mortality in high-income countries, and increased efforts are needed to tackle these major risk factors, particularly smoking and the emerging obesity epidemic.
Journal ArticleDOI
Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials
Jane Armitage,Colin Baigent,Elizabeth H Barnes,D. John Betteridge,Lisa Blackwell,Michael A. Blazing,Louise Bowman,Eugene Braunwald,Robert P Byington,Christopher P. Cannon,Michael Clearfield,Helen M. Colhoun,Rory Collins,Björn Dahlöf,Kelly Davies,Barry R. Davis,James A. de Lemos,John R. Downs,Paul N. Durrington,Jonathan Emberson,Bengt Fellström,Marcus Flather,Ian Ford,Maria Grazia Franzosi,Jordan Fulcher,John H. Fuller,Curt D. Furberg,David L. Gordon,Shinya Goto,Antonio M. Gotto,Heather Halls,Charlie H.S. Harper,C. Morton Hawkins,William G. Herrington,Graham A. Hitman,Hallvard Holdaas,Lisa Holland,Alan G. Jardine,J. Wouter Jukema,John J.P. Kastelein,Sharon Kean,Anthony C Keech,Adrienne Kirby,John Kjekshus,Genell L. Knatterud,Robert H. Knopp,Wolfgang Koenig,Michael J. Koren,Vera Krane,Martin J Landray,John C. LaRosa,Eva Lonn,Peter W. Macfarlane,Stephen MacMahon,Aldo P. Maggioni,Roberto Marchioli,Ian C. Marschner,Borislava Mihaylova,Lemuel A. Moyé,Sabina A. Murphy,Haruo Nakamura,Andrew Neil,Connie B. Newman,Rachel O'Connell,Chris J. Packard,Sarah Parish,Terje R. Pedersen,Richard Peto,Marc A. Pfeffer,Neil Poulter,David Preiss,Christina Reith,Paul M. Ridker,Michele Robertson,Frank M. Sacks,Naveed Sattar,Roland E. Schmieder,Patrick W. Serruys,Peter S. Sever,John Shaw,Charles L. Shear,John Simes,Peter Sleight,Enti Spata,Luigi Tavazzi,Jonathan A. Tobert,Gianni Tognoni,Andrew Tonkin,Stella Trompet,John Varigos,Christoph Wanner,Hans Wedel,Harvey D. White,John Wikstrand,Lars Wilhelmsen,Kate Wilson,R. Young,Salim Yusuf,Faiez Zannad +98 more
TL;DR: A meta-analysis of data from all large statin trials to compare the effects of statin therapy at different ages observed a significant reduction in major vascular events in all age groups.
Journal ArticleDOI
Association Between Diabetes and Cause-Specific Mortality in Rural and Urban Areas of China.
Fiona Bragg,Michael V. Holmes,Michael V. Holmes,Andri Iona,Andri Iona,Yu Guo,Huaidong Du,Huaidong Du,Yiping Chen,Yiping Chen,Zheng Bian,Ling Yang,Ling Yang,William G. Herrington,Derrick A Bennett,Iain Turnbull,Yongmei Liu,Shixian Feng,Junshi Chen,Robert Clarke,Rory Collins,Richard Peto,Liming Li,Liming Li,Zhengming Chen +24 more
TL;DR: Although diabetes was more common in urban areas, it was associated with greater excess mortality in rural areas, and diabetes was associatedwith increased mortality from a range of cardiovascular and noncardiovascular diseases.
Journal ArticleDOI
Impact of renal function on the effects of LDL cholesterol lowering with statin-based regimens: a meta-analysis of individual participant data from 28 randomised trials.
William G. Herrington,Jonathan Emberson,Borislava Mihaylova,Lisa Blackwell,Christina Reith,Marit Dahl Solbu,Patrick B. Mark,Bengt Fellström,Alan G. Jardine,Christoph Wanner,Hallvard Holdaas,Jordan Fulcher,Richard Haynes,Martin J Landray,Anthony C Keech,John Simes,Rory Collins,Colin Baigent +17 more
TL;DR: Despite allowing for the smaller reductions in LDL cholesterol achieved by patients with more advanced chronic kidney disease, the relative reductions in major vascular events observed with statin-based treatment became smaller as eGFR declined, with little evidence of benefit in patients on dialysis.