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William G. Iacono
Researcher at University of Minnesota
Publications - 666
Citations - 55728
William G. Iacono is an academic researcher from University of Minnesota. The author has contributed to research in topics: Twin study & Minnesota Twin Family Study. The author has an hindex of 110, co-authored 648 publications receiving 48886 citations. Previous affiliations of William G. Iacono include Florida State University & University of Zurich.
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Journal ArticleDOI
Next-generation genotype imputation service and methods.
Sayantan Das,Lukas Forer,Sebastian Schönherr,Carlo Sidore,Carlo Sidore,Adam E. Locke,Alan Kwong,Scott I. Vrieze,Emily Y. Chew,Shawn Levy,Matt McGue,David Schlessinger,Dwight Stambolian,Po-Ru Loh,William G. Iacono,Anand Swaroop,Laura J. Scott,Francesco Cucca,Florian Kronenberg,Michael Boehnke,Gonçalo R. Abecasis,Christian Fuchsberger,Christian Fuchsberger,Christian Fuchsberger +23 more
TL;DR: Improvements to imputation machinery are described that reduce computational requirements by more than an order of magnitude with no loss of accuracy in comparison to standard imputation tools.
Journal ArticleDOI
A reference panel of 64,976 haplotypes for genotype imputation
Shane A. McCarthy,Sayantan Das,Warren W. Kretzschmar,Olivier Delaneau,Andrew R. Wood,Alexander Teumer,Hyun Min Kang,Christian Fuchsberger,Petr Danecek,Kevin Sharp,Yang Luo,C Sidore,Alan Kwong,Nicholas J. Timpson,Seppo Koskinen,Scott I. Vrieze,Laura J. Scott,He Zhang,Anubha Mahajan,Jan H. Veldink,Ulrike Peters,Ulrike Peters,Carlos N. Pato,Cornelia M. van Duijn,Christopher E. Gillies,Ilaria Gandin,Massimo Mezzavilla,Arthur Gilly,Massimiliano Cocca,Michela Traglia,Andrea Angius,Jeffrey C. Barrett,D.I. Boomsma,Kari Branham,Gerome Breen,Gerome Breen,Chad M. Brummett,Fabio Busonero,Harry Campbell,Andrew T. Chan,Sai Chen,Emily Y. Chew,Francis S. Collins,Laura J Corbin,George Davey Smith,George Dedoussis,Marcus Dörr,Aliki-Eleni Farmaki,Luigi Ferrucci,Lukas Forer,Ross M. Fraser,Stacey Gabriel,Shawn Levy,Leif Groop,Leif Groop,Tabitha A. Harrison,Andrew T. Hattersley,Oddgeir L. Holmen,Kristian Hveem,Matthias Kretzler,James Lee,Matt McGue,Thomas Meitinger,David Melzer,Josine L. Min,Karen L. Mohlke,John B. Vincent,Matthias Nauck,Deborah A. Nickerson,Aarno Palotie,Aarno Palotie,Michele T. Pato,Nicola Pirastu,Melvin G. McInnis,J. Brent Richards,J. Brent Richards,Cinzia Sala,Veikko Salomaa,David Schlessinger,Sebastian Schoenherr,P. Eline Slagboom,Kerrin S. Small,Tim D. Spector,Dwight Stambolian,Marcus A. Tuke,Jaakko Tuomilehto,Leonard H. van den Berg,Wouter van Rheenen,Uwe Völker,Cisca Wijmenga,Daniela Toniolo,Eleftheria Zeggini,Paolo Gasparini,Matthew G. Sampson,James F. Wilson,Timothy M. Frayling,Paul I.W. de Bakker,Morris A. Swertz,Steven A. McCarroll,Charles Kooperberg,Annelot M. Dekker,David Altshuler,Cristen J. Willer,William G. Iacono,Samuli Ripatti,Nicole Soranzo,Nicole Soranzo,Klaudia Walter,Anand Swaroop,Francesco Cucca,Carl A. Anderson,Richard M. Myers,Michael Boehnke,Mark I. McCarthy,Mark I. McCarthy,Richard Durbin,Gonçalo R. Abecasis,Jonathan Marchini +117 more
TL;DR: A reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies.
Journal ArticleDOI
Etiologic connections among substance dependence, antisocial behavior, and personality: Modeling the externalizing spectrum
Robert F. Krueger,Brian M. Hicks,Christopher J. Patrick,Scott R. Carlson,William G. Iacono,Matt McGue +5 more
TL;DR: A hierarchical biometric model is presented of the origins of comorbidity among substance dependence, antisocial behavior, and a disinhibited personality style, and it is offered as a novel target for future research to reconcile evidence for general and specific causal factors within the externalizing spectrum.
A reference panel of 64,976 haplotypes for genotype imputation
Shane A. McCarthy,Sayantan Das,Warren W. Kretzschmar,Olivier Delaneau,Andrew R. Wood,Alexander Teumer,Hyun Min Kang,Christian Fuchsberger,Petr Danecek,Kevin Sharp,Yang Luo,Carlo Sidorel,Alan Kwong,Nicholas J. Timpson,Seppo Koskinen,Scott I. Vrieze,Laura J. Scott,He Zhang,Anubha Mahajan,Jan H. Veldink,Ulrike Peters,Carlos N. Pato,Cornelia M. van Duijn,Christopher E. Gillies,Ilaria Gandin,Massimo Mezzavilla,Arthur Gilly,Massimiliano Cocca,Michela Traglia,Andrea Angius,Jeffrey C. Barrett,D.I. Boomsma,Kari Branham,Gerome Breen,Chad M. Brummett,Fabio Busonero,Harry Campbell,Andrew T. Chan,Sai Che,Emily Y. Chew,Francis S. Collins,Laura J Corbin,George Davey Smith,George Dedoussis,Marcus Dörr,Aliki-Eleni Farmaki,Luigi Ferrucci,Lukas Forer,Ross M. Fraser,Stacey Gabriel,Shawn Levy,Leif Groop,Tabitha A. Harrison,Andrew T. Hattersley,Oddgeir L. Holmen,Kristian Hveem,Matthias Kretzler,James Lee,Matt McGue,Thomas Meitinger,David Melzer,Josine L. Min,Karen L. Mohlke,John B. Vincent,Matthias Nauck,Deborah A. Nickerson,Aarno Palotie,Michele T. Pato,Nicola Pirastu,Melvin G. McInnis,J. Brent Richards,Cinzia Sala,Veikko Salomaa,David Schlessinger,Sebastian Schoenherr,P. Eline Slagboom,Kerrin S. Small,Tim D. Spector,Dwight Stambolian,Marcus A. Tuke,Jaakko Tuomilehto,Leonard H. van den Berg,Wouter van Rheenen,Uwe Völker,Cisca Wijmenga,Daniela Toniolo,Eleftheria Zeggini,Paolo Gasparini,Matthew G. Sampson,James F. Wilson,Timothy M. Frayling,Paul I.W. de Bakker,Morris A. Swertz,Steven A. McCarroll,Charles Kooperberg,Annelot M. Dekker,David Altshuler,Cristen J. Willer,William G. Iacono,Samuli Ripatti,Nicole Soranzo,Klaudia Walter,Anand Swaroop,Francesco Cucca,Carl A. Anderson,Richard M. Myers,Michael Boehnke,Mark I. McCarthy,Richard Durbin,Gonçalo R. Abecasis,Jonathan Marchini +110 more
TL;DR: In this article, a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry is presented.
Journal ArticleDOI
Genome-wide association study identifies 74 loci associated with educational attainment
Aysu Okbay,Jonathan P. Beauchamp,Mark Alan Fontana,James J. Lee,Tune H. Pers,Cornelius A. Rietveld,Patrick Turley,Guo-Bo Chen,Valur Emilsson,S. Fleur W. Meddens,S. Fleur W. Meddens,S. Fleur W. Meddens,Sven Oskarsson,Joseph K. Pickrell,Kevin Thom,Pascal Timshel,Pascal Timshel,Ronald de Vlaming,Abdel Abdellaoui,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Jonas Bacelis,Clemens Baumbach,Gyda Bjornsdottir,Johannes H. Brandsma,Maria Pina Concas,Jaime Derringer,Nicholas A. Furlotte,Tessel E. Galesloot,Giorgia Girotto,Richa Gupta,Leanne M. Hall,Leanne M. Hall,Sarah E. Harris,Edith Hofer,Momoko Horikoshi,Momoko Horikoshi,Jennifer E. Huffman,Kadri Kaasik,Ioanna P. Kalafati,Robert Karlsson,Augustine Kong,Jari Lahti,Sven J. van der Lee,C. deLeeuw,C. deLeeuw,Penelope A. Lind,Karl-Oskar Lindgren,Tian Liu,Massimo Mangino,Massimo Mangino,Jonathan Marten,Evelin Mihailov,Michael B. Miller,Peter J. van der Most,Christopher Oldmeadow,Antony Payton,Natalia Pervjakova,Natalia Pervjakova,Wouter J. Peyrot,Yong Qian,Olli T. Raitakari,Rico Rueedi,Rico Rueedi,Erika Salvi,Börge Schmidt,Katharina E. Schraut,Jianxin Shi,Albert V. Smith,Raymond A. Poot,Beate St Pourcain,Alexander Teumer,Gudmar Thorleifsson,Niek Verweij,Dragana Vuckovic,Juergen Wellmann,Harm-Jan Westra,Harm-Jan Westra,Jingyun Yang,Wei Zhao,Zhihong Zhu,Behrooz Z. Alizadeh,Najaf Amin,Andrew Bakshi,Sebastian E. Baumeister,Sebastian E. Baumeister,Ginevra Biino,Klaus Bønnelykke,Patricia A. Boyle,Harry Campbell,Francesco P. Cappuccio,Gail Davies,Jan-Emmanuel De Neve,Panos Deloukas,Panos Deloukas,Ilja Demuth,Jun Ding,Peter Eibich,Peter Eibich,Lewin Eisele,Niina Eklund,David M. Evans,David M. Evans,Jessica D. Faul,Mary F. Feitosa,Andreas J. Forstner,Ilaria Gandin,Bjarni Gunnarsson,Bjarni V. Halldorsson,Bjarni V. Halldorsson,Tamara B. Harris,Andrew C. Heath,Lynne J. Hocking,Elizabeth G. Holliday,Georg Homuth,Michael A. Horan,Jouke-Jan Hottenga,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Peter K. Joshi,Astanand Jugessur,Marika Kaakinen,Mika Kähönen,Stavroula Kanoni,Liisa Keltigangas-Jarvinen,Lambertus A. Kiemeney,Ivana Kolcic,Seppo Koskinen,Aldi T. Kraja,Martin Kroh,Zoltán Kutalik,Zoltán Kutalik,Antti Latvala,Lenore J. Launer,Maël Lebreton,Douglas F. Levinson,Paul Lichtenstein,Peter Lichtner,David C. Liewald,Anu Loukola,Pamela A. F. Madden,Reedik Mägi,Tomi Mäki-Opas,Riccardo E. Marioni,Riccardo E. Marioni,Pedro Marques-Vidal,Gerardus A. Meddens,George McMahon,Christa Meisinger,Thomas Meitinger,Y. Milaneschi,Lili Milani,Grant W. Montgomery,Ronny Myhre,Christopher P. Nelson,Christopher P. Nelson,Dale R. Nyholt,William E R Ollier,Aarno Palotie,Lavinia Paternoster,Nancy L. Pedersen,K. Petrovic,David J. Porteous,Katri Räikkönen,Susan M. Ring,Antonietta Robino,Olga Rostapshova,Igor Rudan,Aldo Rustichini,Veikko Salomaa,Alan R. Sanders,Alan R. Sanders,Antti-Pekka Sarin,Antti-Pekka Sarin,Helena Schmidt,Rodney J. Scott,Blair H. Smith,Jennifer A. Smith,Jan A. Staessen,Jan A. Staessen,Elisabeth Steinhagen-Thiessen,Konstantin Strauch,Antonio Terracciano,Martin D. Tobin,Sheila Ulivi,Simona Vaccargiu,Lydia Quaye,Frank J. A. van Rooij,Cristina Venturini,Cristina Venturini,Anna A. E. Vinkhuyzen,Uwe Völker,Henry Völzke,Judith M. Vonk,Diego Vozzi,Johannes Waage,Johannes Waage,Erin B. Ware,Gonneke Willemsen,John Attia,David A. Bennett,Klaus Berger,Lars Bertram,Lars Bertram,Hans Bisgaard,Dorret I. Boomsma,Ingrid B. Borecki,Ute Bültmann,Christopher F. Chabris,Francesco Cucca,Daniele Cusi,Daniele Cusi,Ian J. Deary,George Dedoussis,Cornelia M. van Duijn,Johan G. Eriksson,Barbara Franke,Lude Franke,Paolo Gasparini,Paolo Gasparini,Pablo V. Gejman,Pablo V. Gejman,Christian Gieger,Hans-Jörgen Grabe,Jacob Gratten,Patrick J. F. Groenen,Vilmundur Gudnason,Pim van der Harst,Caroline Hayward,David A. Hinds,Wolfgang Hoffmann,Elina Hyppönen,Elina Hyppönen,William G. Iacono,Bo Jacobsson,Marjo-Riitta Järvelin,Karl-Heinz Jöckel,Jaakko Kaprio,Jaakko Kaprio,Sharon L.R. Kardia,Terho Lehtimäki,Steven F. Lehrer,Steven F. Lehrer,Patrik K. E. Magnusson,Nicholas G. Martin,Matt McGue,Andres Metspalu,Neil Pendleton,Neil Pendleton,Brenda W.J.H. Penninx,Markus Perola,Markus Perola,Nicola Pirastu,Mario Pirastu,Ozren Polasek,Ozren Polasek,Danielle Posthuma,Christine Power,Michael A. Province,Nilesh J. Samani,Nilesh J. Samani,David Schlessinger,Reinhold Schmidt,Thorkild I. A. Sørensen,Thorkild I. A. Sørensen,Tim D. Spector,Kari Stefansson,Kari Stefansson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Roy Thurik,Nicholas J. Timpson,Henning Tiemeier,Joyce Y. Tung,André G. Uitterlinden,Veronique Vitart,Peter Vollenweider,David R. Weir,James F. Wilson,Alan F. Wright,Dalton Conley,Robert F. Krueger,George Davey Smith,Albert Hofman,David Laibson,Sarah E. Medland,Michelle N. Meyer,Jian Yang,Magnus Johannesson,Peter M. Visscher,Tõnu Esko,Philipp Koellinger,Philipp Koellinger,Philipp Koellinger,David Cesarini,Daniel J. Benjamin +296 more
TL;DR: In this article, the results of a genome-wide association study (GWAS) for educational attainment were reported, showing that single-nucleotide polymorphisms associated with educational attainment disproportionately occur in genomic regions regulating gene expression in the fetal brain.