W
William J. Martin
Researcher at National Institutes of Health
Publications - 270
Citations - 17587
William J. Martin is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Epitope & Antigen. The author has an hindex of 63, co-authored 264 publications receiving 16715 citations. Previous affiliations of William J. Martin include University College London & Brown University.
Papers
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Journal ArticleDOI
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
Michael J. Caterina,A. Leffler,Annika B. Malmberg,William J. Martin,Jodie A. Trafton,K. R. Petersen-Zeitz,Martin Koltzenburg,Allan I. Basbaum,David Julius +8 more
TL;DR: Sensory neurons from mice lacking VR1 are severely deficient in their responses to each of these noxious stimuli and are impaired in the detection of painful heat, and showed little thermal hypersensitivity in the setting of inflammation.
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Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction.
TL;DR: The rapid and sensitive analysis of HPV in normal and pathological tissues using this technique may contribute significantly to identifying the role of HPV as a risk factor in carcinoma.
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Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography.
Joshua B. Burt,Murat Demirtas,William J. Eckner,Natasha M. Navejar,Jie Lisa Ji,William J. Martin,Alberto Bernacchia,Alan Anticevic,John D. Murray +8 more
TL;DR: In this paper, a noninvasive neuroimaging measure, T1w/T2w mapping, was used to identify a hierarchical axis linking cortical transcription and anatomy, along which gradients of micro-scale properties may contribute to the macroscale specialization of cortical function.
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An analgesia circuit activated by cannabinoids
TL;DR: It is shown that a brainstem circuit that contributes to the pain-suppressing effects of morphine is also required for the analgesic effects of cannabinoids, and that cannabinoids are indeed centrally acting analgesics with a new mechanism of action.
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Activation of natural regulatory T cells by IgG Fc–derived peptide “Tregitopes”
Anne S. De Groot,Leonard Moise,Julie A. McMurry,Erik Wambre,Laurence Van Overtvelt,Philippe Moingeon,David W. Scott,William J. Martin +7 more
TL;DR: In this paper, the authors identified at least two highly promiscuous major histocompatibility complex class II T-cell epitopes in the Fc fragment of IgG that are capable of specifically activating CD4+CD25HiFoxP3+ natural regulatory T cells (nTRegs).