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William J Salerno
Researcher at Baylor College of Medicine
Publications - 51
Citations - 2619
William J Salerno is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Population & Exome sequencing. The author has an hindex of 18, co-authored 40 publications receiving 1573 citations. Previous affiliations of William J Salerno include Regeneron & Human Genome Sequencing Center.
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Journal ArticleDOI
Exome sequencing and characterization of 49,960 individuals in the UK Biobank.
Cristopher V. Van Hout,Ioanna Tachmazidou,Ioanna Tachmazidou,Joshua D. Backman,Joshua D. Hoffman,Daren Liu,Ashutosh K. Pandey,Claudia Gonzaga-Jauregui,Shareef Khalid,Bin Ye,Nilanjana Banerjee,Alexander H. Li,Colm O'Dushlaine,Anthony Marcketta,Jeffrey Staples,Claudia Schurmann,Claudia Schurmann,Alicia Hawes,Evan Maxwell,Leland Barnard,Alexander Lopez,John Penn,Lukas Habegger,Andrew Blumenfeld,Xiaodong Bai,Sean O'Keeffe,Ashish Yadav,Kavita Praveen,Marcus B. Jones,William J Salerno,Wendy K. Chung,Ida Surakka,Cristen J. Willer,Kristian Hveem,Joseph B. Leader,David J. Carey,David H. Ledbetter,Lon R. Cardon,George D. Yancopoulos,Aris N. Economides,Giovanni Coppola,Alan R. Shuldiner,Suganthi Balasubramanian,Michael N. Cantor,Matthew R. Nelson,John C. Whittaker,Jeffrey G. Reid,Jonathan Marchini,John D. Overton,Robert A. Scott,Gonçalo R. Abecasis,Laura M. Yerges-Armstrong,Aris Baras +52 more
TL;DR: The release of exome-sequence data for the first 49,960 study participants, revealing approximately 4 million coding variants, illustrating the power of characterizing LOF variants in this population through association analyses across 1,730 phenotypes and demonstrating the value of genome sequencing in large population-based studies.
Journal ArticleDOI
Launching genomics into the cloud: deployment of Mercury, a next generation sequence analysis pipeline.
Jeffrey G. Reid,Andrew Carroll,Narayanan Veeraraghavan,Mahmoud Dahdouli,Andreas Sundquist,Adam C. English,Matthew N. Bainbridge,Simon D. M. White,William J Salerno,Christian J. Buhay,Fuli Yu,Donna M. Muzny,Richard Daly,Geoff Duyk,Richard A. Gibbs,Eric Boerwinkle,Eric Boerwinkle +16 more
TL;DR: The Mercury analysis pipeline is developed and deployed in local hardware and the Amazon Web Services cloud via the DNAnexus platform and provides accurate and reproducible genomic results at scales ranging from individuals to large cohorts.
Journal ArticleDOI
Exome sequencing and analysis of 454,787 UK Biobank participants.
Joshua D. Backman,Alexander H. Li,Anthony Marcketta,Dylan Sun,Joelle Mbatchou,Michael D. Kessler,Christian Benner,Daren Liu,Adam E. Locke,Suganthi Balasubramanian,Ashish Yadav,Nilanjana Banerjee,Christopher E. Gillies,Amy Damask,Simon Liu,Xiaodong Bai,Alicia Hawes,Evan Maxwell,Lauren Gurski,Kyoko Watanabe,Jack A. Kosmicki,Veera M. Rajagopal,Jason Mighty,Marcus B. Jones,Lyndon J. Mitnaul,Eli A. Stahl,Giovanni Coppola,Eric Jorgenson,Lukas Habegger,William J Salerno,Alan R. Shuldiner,Luca A. Lotta,John D. Overton,Michael N. Cantor,Jeffrey G. Reid,George D. Yancopoulos,Hyun Min Kang,Jonathan Marchini,Aris Baras,Gonçalo R. Abecasis,Manuel A. R. Ferreira +40 more
TL;DR: This paper used exome sequencing to explore protein altering variants and their consequences in 454,787 UK Biobank study participants and identified 12 million coding variants, including ~1 million loss-of-function and ~1.8 million deleterious missense variants.
Journal ArticleDOI
Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation
Joshua C. Bis,Xueqiu Jian,Brian W. Kunkle,Yuning Chen,Kara L. Hamilton-Nelson,William S. Bush,William J Salerno,Daniel Lancour,Yiyi Ma,Alan E. Renton,Edoardo Marcora,John J. Farrell,Yi Zhao,Liming Qu,Shahzad Ahmad,Najaf Amin,Philippe Amouyel,Philippe Amouyel,Philippe Amouyel,Gary W. Beecham,Jennifer E. Below,Dominique Campion,Laura B. Cantwell,Camille Charbonnier,Jaeyoon Chung,Paul K. Crane,Carlos Cruchaga,L. Adrienne Cupples,Jean-François Dartigues,Stéphanie Debette,Jean-François Deleuze,Lucinda Fulton,Stacey Gabriel,Emmanuelle Génin,Richard A. Gibbs,Alison Goate,Benjamin Grenier-Boley,Namrata Gupta,Jonathan L. Haines,Aki S. Havulinna,Aki S. Havulinna,Seppo Helisalmi,Mikko Hiltunen,Daniel P. Howrigan,Daniel P. Howrigan,M. Arfan Ikram,Jaakko Kaprio,Jan Konrad,Amanda B. Kuzma,Eric S. Lander,Mark Lathrop,Terho Lehtimäki,Honghuang Lin,Kari Mattila,Richard Mayeux,Donna M. Muzny,Waleed Nasser,Benjamin M. Neale,Benjamin M. Neale,Kwangsik Nho,Gaël Nicolas,Devanshi Patel,Margaret A. Pericak-Vance,Markus Perola,Markus Perola,Markus Perola,Bruce M. Psaty,Olivier Quenez,Farid Rajabli,Richard Redon,Christiane Reitz,Anne M. Remes,Anne M. Remes,Veikko Salomaa,Chloé Sarnowski,Helena Schmidt,Michael A. Schmidt,Reinhold Schmidt,Hilkka Soininen,Timothy A. Thornton,Giuseppe Tosto,Christophe Tzourio,Sven J. van der Lee,Cornelia M. van Duijn,Otto Valladares,Badri N. Vardarajan,Li-San Wang,Weixin Wang,Ellen M. Wijsman,Richard K. Wilson,Daniela Witten,Kim C. Worley,Xiaoling Zhang,Alzheimer’s Disease Sequencing,Alzheimer’s Disease Sequencing,Alzheimer’s Disease Sequencing,Céline Bellenguez,Jean-Charles Lambert,Mitja I. Kurki,Mitja I. Kurki,Mitja I. Kurki,Aarno Palotie,Aarno Palotie,Aarno Palotie,Mark J. Daly,Mark J. Daly,Mark J. Daly,Eric Boerwinkle,Eric Boerwinkle,Kathryn L. Lunetta,Anita L. DeStefano,Josée Dupuis,Eden R. Martin,Gerard D. Schellenberg,Sudha Seshadri,Sudha Seshadri,Adam C. Naj,Myriam Fornage,Lindsay A. Farrer +118 more
TL;DR: The Alzheimer’s Disease Sequencing Project undertook whole exome sequencing in 5,740 late-onset Alzheimer disease cases and 5,096 cognitively normal controls primarily of European ancestry, identifying novel and predicted functional genetic variants in genes previously associated with AD.
Journal ArticleDOI
Mapping and Characterization of Structural Variation in 17,795 Human Genomes
Haley J. Abel,David E. Larson,Allison A. Regier,Colby Chiang,Indraniel Das,Krishna L. Kanchi,Ryan M. Layer,Benjamin M. Neale,Benjamin M. Neale,William J Salerno,Catherine Reeves,Steven Buyske,Nhgri Centers for Common Disease Genomics,Tara C. Matise,Donna M. Muzny,Michael C. Zody,Eric S. Lander,Eric S. Lander,Eric S. Lander,Susan K. Dutcher,Nathan O. Stitziel,Ira M. Hall +21 more
TL;DR: A scalable pipeline is used to map and characterize structural variants in 17,795 deeply sequenced human genomes to create the largest, to the authors' knowledge, whole-genome-sequencing-based structural variant resource so far and infer the dosage sensitivity of genes and noncoding elements.