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William L. McGuire
Researcher at University of Texas Health Science Center at San Antonio
Publications - 288
Citations - 39825
William L. McGuire is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Breast cancer & Estrogen receptor. The author has an hindex of 85, co-authored 288 publications receiving 39032 citations. Previous affiliations of William L. McGuire include University of Akron & University of Texas at Austin.
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Journal ArticleDOI
Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
Dennis J. Slamon,Gary M. Clark,Steven G. Wong,Wendy J. Levin,Axel Ullrich,William L. McGuire +5 more
TL;DR: Amplification of the HER-2/neu gene was a significant predictor of both overall survival and time to relapse in patients with breast cancer, and had greater prognostic value than most currently used prognostic factors in lymph node-positive disease.
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Estrogen receptors in human breast cancer.
TL;DR: Specific quantitative techniques have been used to measure the cytoplasmic estradiol-binding protein (EBP) in human mammary carcinoma tissue specimens, indicating an excellent correlation between the presence of abundant tumor EBP and endocrine-induced breast cancer regressions.
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Estrogen control of progesterone receptor in human breast cancer. Correlation with nuclear processing of estrogen receptor.
TL;DR: MCF-7 cells of human breast cancer origin responded to estradiol (E) treatment with increased levels of progesterone receptor (PgR) showing that human breast cells which have undergone malignant changes can continue to synthesize a specific protein under hormone control.
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Association of p53 Protein Expression With Tumor Cell Proliferation Rate and Clinical Outcome in Node-Negative Breast Cancer
D. C. Allred,Gary M. Clark,Richard M. Elledge,Suzanne A. W. Fuqua,Richard W. Brown,Gary C. Chamness,C K Osborne,William L. McGuire +7 more
TL;DR: In this article, the p53 (also known as TP53) tumor suppressor gene encodes for a nuclear phosphoprotein thought to regulate proliferation of normal cells, and the relationship between levels of mutant p53 protein expression, tumor cell proliferation rate, and clinical outcome in patients with node-negative breast cancer was investigated.
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The value of estrogen and progesterone receptors in the treatment of breast cancer
TL;DR: Preliminary analysis suggests that the presence of PgR may be a better marker of tumor hormone dependence than quantitative ER, which is an important independent prognostic indicator of higher rate of recurrence and shorter survival.