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William Mansfield
Researcher at University of Cambridge
Publications - 20
Citations - 2385
William Mansfield is an academic researcher from University of Cambridge. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 10, co-authored 19 publications receiving 1982 citations. Previous affiliations of William Mansfield include Wellcome Trust Centre for Stem Cell Research.
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Journal ArticleDOI
Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human
Yasuhiro Takashima,Ge Guo,Remco Loos,Jennifer Nichols,Gabriella Ficz,Felix Krueger,David Oxley,Fátima Santos,James Clarke,William Mansfield,Wolf Reik,Paul Bertone,Paul Bertone,Austin Smith +13 more
TL;DR: It is reported that short-term expression of two components, NANOG and KLF2, is sufficient to ignite other elements of the network and reset the human pluripotent state and demonstrate feasibility of installing and propagating functional control circuitry for ground-state pluripotency in human cells.
Journal ArticleDOI
Naive pluripotency is associated with global DNA hypomethylation
Harry G. Leitch,Kirsten R. McEwen,Aleksandra Turp,Vesela Encheva,Thomas L. Carroll,Nils Grabole,Nils Grabole,William Mansfield,Buhe Nashun,Jaysen G Knezovich,Austin Smith,M. Azim Surani,M. Azim Surani,Petra Hajkova +13 more
TL;DR: It is established that culture in 2i instills a naive pluripotent state with a distinctive epigenetic configuration that parallels molecular features observed in both the preimplantation epiblast and nascent PGCs.
Journal ArticleDOI
NuRD Suppresses Pluripotency Gene Expression to Promote Transcriptional Heterogeneity and Lineage Commitment
Nicola Reynolds,Paulina A. Latos,Antony Hynes-Allen,Antony Hynes-Allen,Remco Loos,Donna Leaford,Donna Leaford,Aoife O'Shaughnessy,Aoife O'Shaughnessy,Olukunbi Mosaku,Olukunbi Mosaku,Jason Signolet,Jason Signolet,Philip Brennecke,Tuezer Kalkan,Tuezer Kalkan,Ita Costello,Peter Humphreys,Peter Humphreys,William Mansfield,William Mansfield,Kentaro Nakagawa,John Strouboulis,Axel Behrens,Paul Bertone,Paul Bertone,Brian Hendrich,Brian Hendrich +27 more
TL;DR: The Nucleosome Remodeling and Deacetylation (NuRD) complex, which is required for ESC lineage commitment, modulates both transcriptional heterogeneity and the dynamic range of a set of pluripotency genes in ESCs.
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Validated germline-competent embryonic stem cell lines from nonobese diabetic mice.
Jennifer Nichols,Kenneth Jones,Kenneth Jones,Jenny M. Phillips,Stephen A. Newland,Mila Roode,Mila Roode,William Mansfield,William Mansfield,Austin Smith,Austin Smith,Anne Cooke +11 more
TL;DR: The derivation of NOD ES cell lines capable of generating chimeric mice after stable genetic modification are described, which will enable the dissection of closely linked loci and the role they have in the onset of type 1 diabetes but also facilitate the generation of new transgenics.
Journal ArticleDOI
Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst
Gloryn Chia Le Bin,Silvia Muñoz-Descalzo,Silvia Muñoz-Descalzo,Agata Kurowski,Agata Kurowski,Harry G. Leitch,Xinghua Lou,William Mansfield,Charles Etienne-Dumeau,Nils Grabole,Nils Grabole,Carla Mulas,Hitoshi Niwa,Anna-Katerina Hadjantonakis,Jennifer Nichols +14 more
TL;DR: It is concluded that cell fate decisions within the inner cell mass are dependent upon Oct4 and that Oct4 is not cell-autonomously required for the differentiation of primitive endoderm derivatives, as long as an appropriate developmental environment is established.