William P. Gilks

TL;DR: The identification of two homozygous mutations affecting the PINK1 kinase domain in three consanguineous PARK6 families provide a direct molecular link between mitochondria and the pathogenesis of PD.

TL;DR: The cloning of a novel gene that contains missense mutations segregating with PARK8-linked PD in five families from England and Spain is described and this protein is named dardarin, derived from the Basque word dardara, meaning tremor, because of the tremor observed in PD.

TL;DR: It is shown that a common single Mendelian mutation, 2877510 g-->A, which produces a glycine to serine aminoacid substitution at codon 2019 (Gly2019 ser), in idiopathic Parkinson's disease, and suggested that testing for this mutation will be important in the management and genetic counselling of patients with Parkinson's Disease.

TL;DR: The data suggest that parkinsonism caused by mutations in LRRK2 is likely to represent the commonest locus for autosomal dominant Parkinson's disease with a phenotype, pathology and in vivo imaging similar to idiopathic, late-onset Parkinson’s disease.

TL;DR: A cellular model system of LBs, namely induction of aggresomes, is used to determine how a mitochondrial protein, such as PINK1, can localize to aggregates and provide valuable insights into the mechanisms of LB formation in PD.