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William P. Tansey
Researcher at Vanderbilt University
Publications - 106
Citations - 7897
William P. Tansey is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Transcription factor & Chromatin. The author has an hindex of 37, co-authored 97 publications receiving 7189 citations. Previous affiliations of William P. Tansey include Watson School of Biological Sciences & Vanderbilt University Medical Center.
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Journal ArticleDOI
How the ubiquitin–proteasome system controls transcription
TL;DR: The deep mechanistic connections between transcription and the ubiquitin–proteasome system are discussed, and how the intersection of these processes tightly controls expression of the genetic information is highlighted.
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From silencing to gene expression: real-time analysis in single cells.
Susan M. Janicki,Toshiro Tsukamoto,Simone E Salghetti,William P. Tansey,Ravi Sachidanandam,Kannanganattu V. Prasanth,Thomas Ried,Yaron Shav-Tal,Edouard Bertrand,Robert H. Singer,David L. Spector +10 more
TL;DR: An inducible system to visualize gene expression at the levels of DNA, RNA and protein in living cells is developed, able to correlate changes in chromatin structure with the progression of transcriptional activation allowing for a real-time integrative view of gene expression.
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Skp2 Regulates Myc Protein Stability and Activity
So Young Kim,Andreas Herbst,Kathryn A Tworkowski,Kathryn A Tworkowski,Simone E Salghetti,William P. Tansey +5 more
TL;DR: It is reported that the oncop protein and Ub ligase Skp2 regulates Myc ubiquitylation and stability, and an unexpected oncoprotein connection is revealed that may play an important role in controlling cell growth in normal and cancer cells.
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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants
Michael T. Hemann,Anka Bric,Julie Teruya-Feldstein,Andreas Herbst,Jonas Nilsson,Carlos Cordon-Cardo,John L. Cleveland,William P. Tansey,Scott W. Lowe,Scott W. Lowe +9 more
TL;DR: It is reported that two common mutant MYC alleles derived from human Burkitt's lymphoma uncouple proliferation from apoptosis and, as a result, are more effective than wild-type MYC at promoting B cell lymphomagenesis in mice.
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Destruction of Myc by ubiquitin‐mediated proteolysis: cancer‐associated and transforming mutations stabilize Myc
TL;DR: The data reveal a complex network of interactions regulating Myc destruction, and imply that enhanced protein stability contributes to oncogenic transformation by mutant Myc proteins.