W
William T. Dauer
Researcher at University of Texas Southwestern Medical Center
Publications - 104
Citations - 12683
William T. Dauer is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Dystonia & LRRK2. The author has an hindex of 41, co-authored 96 publications receiving 11381 citations. Previous affiliations of William T. Dauer include Allen Institute for Brain Science & Columbia University.
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Journal ArticleDOI
Parkinson's disease: Mechanisms and models
TL;DR: PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process.
Journal ArticleDOI
Dopamine-modified α-synuclein blocks chaperone-mediated autophagy
Marta Martinez-Vicente,Zsolt Tallóczy,Susmita Kaushik,Ashish C. Massey,Joseph R. Mazzulli,Eugene V. Mosharov,Roberto Hodara,Ross A. Fredenburg,Du Chu Wu,Antonia Follenzi,William T. Dauer,Serge Przedborski,Harry Ischiropoulos,Peter T. Lansbury,David Sulzer,Ana Maria Cuervo +15 more
TL;DR: It is proposed that dopamine-induced autophagic inhibition could explain the selective degeneration of PD dopaminergic neurons through blockage of CMA, which increases cellular vulnerability to stressors.
Journal ArticleDOI
Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP.
William T. Dauer,Nikolai Kholodilov,Miquel Vila,Anne Cecile Trillat,Rose E. Goodchild,Kristin E. Larsen,Roland G. W. Staal,Kim Tieu,Yvonne Schmitz,Chao Annie Yuan,Marcelo Rocha,Vernice Jackson-Lewis,Steven M. Hersch,David Sulzer,Serge Przedborski,Robert E. Burke,René Hen +16 more
TL;DR: It is shown that α-synuclein null mice display striking resistance to MPTP-induced degeneration of DA neurons and DA release, and this resistance appears to result from an inability of the toxin to inhibit complex I.
Journal ArticleDOI
Interplay of LRRK2 with chaperone-mediated autophagy
Samantha J. Orenstein,Sheng-Hang Kuo,Inmaculada Tasset,Esperanza Arias,Hiroshi Koga,Irene Fernandez-Carasa,Etty Cortes,Lawrence S. Honig,William T. Dauer,Antonella Consiglio,Antonella Consiglio,Angel Raya,David Sulzer,Ana Maria Cuervo +13 more
TL;DR: This newly described LRRK2 self-perpetuating inhibitory effect on CMA could underlie toxicity in Parkinson's disease by compromising the degradation of α-synuclein, another Parkinson’s disease–related protein degraded by this pathway.
Journal ArticleDOI
Cortical 5-HT2A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice
Noelia V. Weisstaub,Mingming Zhou,Alena Lira,Evelyn K. Lambe,Evelyn K. Lambe,Javier González-Maeso,Jean-Pierre Hornung,Etienna Sibille,Etienna Sibille,Mark D. Underwood,Shigeyoshi Itohara,William T. Dauer,Mark S. Ansorge,Emanuela Morelli,J. John Mann,Miklós Tóth,George K. Aghajanian,Stuart C. Sealfon,René Hen,Jay A. Gingrich +19 more
TL;DR: It is demonstrated that global disruption of 5-HT2A receptor (5HT2AR) signaling in mice reduces inhibition in conflict anxiety paradigms without affecting fear-conditioned and depression-related behaviors.