Author
William Tasman
Other affiliations: Thomas Jefferson University Hospital, Thomas Jefferson University
Bio: William Tasman is an academic researcher from Wills Eye Institute. The author has contributed to research in topics: Retinopathy of prematurity & Retinal detachment. The author has an hindex of 49, co-authored 167 publications receiving 10053 citations. Previous affiliations of William Tasman include Thomas Jefferson University Hospital & Thomas Jefferson University.
Papers published on a yearly basis
Papers
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01 Jan 2013
TL;DR: This randomized clinical trial enrolled 47 FM patients with chronic insomnia complaints and compared CBT, sleep hygiene (SH) instructions, and usual FM care alone, finding no difference in outcome measures.
Abstract: Methods: This randomized clinical trial enrolled 47 FM patients with chronic insomnia complaints. The study compared CBT, sleep hygiene (SH) instructions, and usual FM care alone. Outcome measures were subjective (sleep logs) and objective (actigraphy) total sleep time, sleep efficiency, total wake time, sleep latency, wake time after sleep onset, and questionnaire measures of global insomnia symptoms, pain, mood, and quality of life.
1,009 citations
TL;DR: It is shown that Norrin and Fz4 function as a ligand-receptor pair that plays a central role in vascular development in the eye and ear, and it is indicated that ligands unrelated to Wnts can act through Fz receptors.
818 citations
Book•
01 Jun 1993
TL;DR: A reference work, covering those aspects of the basic sciences which relate to ophthalmology that are related to ocularmology.
Abstract: A reference work, covering those aspects of the basic sciences which relate to ophthalmology.
733 citations
Johns Hopkins University1, University of Wisconsin-Madison2, Bascom Palmer Eye Institute3, University of Minnesota4, Massachusetts Eye and Ear Infirmary5, University of Illinois at Chicago6, Oklahoma State University Center for Health Sciences7, Albany Medical College8, University of Iowa9, Wills Eye Institute10, University of Utah11, University of Puerto Rico12, Wayne State University13, University of Washington14, University of Maryland, Baltimore15
TL;DR: Data from the Diabetic Retinopathy Study (DRS) show that photocoagulad inhibited the progression of retinopathy, and beneficial effects were noted to some degree in all those stages of diabeticretinopathy which were included in the Study.
579 citations
TL;DR: In this article, the authors complete the classification of retinopathy of prematurity (ROP) begun with the publication of the recent article on the subject entitled, "An International Classification of Retinopathopathy of Prematurity" (ICROP), which embodied three major concepts for the description of the early phases of the disease: specifying its location by zones of retinal involvement; recording the extent of reterence involvement by clock hours; and staging the disease according to the degree of vascular lesions observed (stages 1 through 4).
Abstract: The purpose of this article is to complete the classification of retinopathy of prematurity (ROP) begun with the publication of the recent article on the subject entitled, "An International Classification of Retinopathy of Prematurity" (ICROP). 1-3 The previously published classification embodied three major concepts for the description of the early phases of the disease: specifying its location by zones of retinal involvement; recording the extent of retinal involvement by clock hours; and, finally, staging the disease according to the degree of vascular lesions observed (stages 1 through 4). That article specified posterior dilatation and tortuosity of retinal vessels as ominous prognostic signs. The committee that authored it left unclassified the sequelae that encompass the cicatricial phase of the disease. It recommended the use of the Reese classification 4 until a more satisfactory one could be developed. The reasons for completing the classification of the end stages of ROP at this
410 citations
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TL;DR: In this article, Anderson et al. proposed a new FAHA Chair, Jeffrey L. Anderson, MD, FACC, FAHA, Chair-Elect, Alice K. Jacobs et al., this article and Biykem Bozkurt.
11,386 citations
TL;DR: Strong recommendations apply to most patients, whereas weak recommendations are sensitive to differences among patients, including their preferences.
5,924 citations
TL;DR: The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels, and that receptor-ligand specificity and feedback loops help to determine WNT signaling outputs.
Abstract: Tight control of cell-cell communication is essential for the generation of a normally patterned embryo. A critical mediator of key cell-cell signaling events during embryogenesis is the highly conserved Wnt family of secreted proteins. Recent biochemical and genetic analyses have greatly enriched our understanding of how Wnts signal, and the list of canonical Wnt signaling components has exploded. The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels. In addition, receptor-ligand specificity and feedback loops help to determine Wnt signaling outputs. Wnts are required for adult tissue maintenance, and perturbations in Wnt signaling promote both human degenerative diseases and cancer. The next few years are likely to see novel therapeutic reagents aimed at controlling Wnt signaling in order to alleviate these conditions.
5,129 citations
TL;DR: A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal transduction cascade over the last two decades, finding that Germline mutations in the Wnt pathway cause several hereditary diseases, and somatic mutations are associated with cancer of the intestine and a variety of other tissues.
5,042 citations
TL;DR: Some key aspects of Wnt/beta-catenin signaling in human diseases including congenital malformations, cancer, and osteoporosis are highlighted, and potential therapeutic implications are discussed.
4,926 citations