W
Willy Haefely
Researcher at Hoffmann-La Roche
Publications - 113
Citations - 7925
Willy Haefely is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Benzodiazepine & GABAA receptor. The author has an hindex of 46, co-authored 113 publications receiving 7848 citations.
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Journal ArticleDOI
Selective antagonists of benzodiazepines.
Walter Hunkeler,Hanns Möhler,L. Pieri,P. Polc,E. P. Bonetti,R. Cumin,R. Schaffner,Willy Haefely +7 more
TL;DR: The main properties of a representative of this novel class of specific benzodiazepine antagonists are described, whose unique pharmacological activity is to prevent or abolish in a highly selective manner at the receptor level all the characteristic centrally mediated effects of active Benzodiazepines.
Journal ArticleDOI
Co-localization of GABA A receptors and benzodiazepine receptors in the brain shown by monoclonal antibodies
P. Schoch,J. G. Richards,P. Häring,Bela Takacs,C. Stähli,Theophil Staehelin,Willy Haefely,Hanns Möhler +7 more
TL;DR: Because the monoclonal antibodies cross-react with human brain, they provide a means for elucidating those CNS disorders which may be linked to a dysfunction of a GABAA receptor, and two constituent proteins were identified immunologically.
Journal ArticleDOI
Benzodiazepine antagonist Ro 15-1788: Neurological and behavioral effects
E. P. Bonetti,L. Pieri,R. Cumin,R. Schaffner,Pieri M,Elkan Gamzu,Rita K. M. Müller,Willy Haefely +7 more
TL;DR: The imidazobenzodiazepinone Ro 15-1788 was highly selective in that it acted against CNS effects induced by benzodiazepines but not against those produced by other depressants, such as phenobarbitone, meprobamate, ethanol, and valproate.
Journal Article
Recent advances in the molecular pharmacology of Benzodiazepine receptors and in the structure-activity relationships of their agonists and antagonists
Journal ArticleDOI
A three-state model of the benzodiazepine receptor explains the interactions between the benzodiazepine antagonist Ro 15-1788, benzodiazepine tranquilizers, beta-carbolines, and phenobarbitone.
TL;DR: The specific benzodiazepine antagonist, Ro 15-1788, while not affecting dorsal root potentials, hippocampal population spikes or phenobarbitone-induced motor performance depression, abolished the effects of β-CCE on the three parameters and similar effects ofβ-CCM on the spinal cord and motor performance.